The reaction of Pt-antitumor drugs with selected nucleophiles. I: The reaction of cis-[Pt(NH3)2Cl2] with glycine

Various Pt(II)-glycine coordination compounds were characterized by 1H and 13C NMR spectroscopy, some of them also by electrophoretic and chromatographic behavior. The results were applied to the analysis of the reaction mixtures of cis-[Pt(NH3)2Cl2] and glycine obtained under various conditions. Ci...

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Veröffentlicht in:	Journal of inorganic biochemistry 1985, Vol.23 (1), p.43-53
Hauptverfasser:	PIVCOVA, H, SAUDEK, V, NOSKOVA, D, DROBNIK, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - analysis Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Cisplatin - analysis Coordination compounds Electrophoresis Exact sciences and technology Glycine - analysis Hydrogen-Ion Concentration Inorganic chemistry and origins of life Magnetic Resonance Spectroscopy Molecular Conformation Preparations and properties Spectrophotometry, Ultraviolet Temperature Time Factors
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Zusammenfassung:	Various Pt(II)-glycine coordination compounds were characterized by 1H and 13C NMR spectroscopy, some of them also by electrophoretic and chromatographic behavior. The results were applied to the analysis of the reaction mixtures of cis-[Pt(NH3)2Cl2] and glycine obtained under various conditions. Cis-[Pt(NH3)2Cl2] reacts with glycine to give cis-diammine-(glycine-N,O)-Pt(II) and cis-diammine-bis(glycine-N-)Pt(II). Their ratio depends primarily on the pH of the reaction medium. Conformation of these compounds is discussed based on the observed Pt-C and Pt-H NMR coupling constants.
ISSN:	0162-0134 1873-3344