Molecular cloning of crustacean putative molt-inhibiting hormone (MIH) precursor

A cDNA encoding the complete precursor of the putative molt-inhibiting hormone (MIH) of the shore crab, Carcinus maenas, was isolated and sequenced. The precursor consists of a putative 35 amino acid signal peptide and the 78 amino acid mature MIH. The deduced MIH amino acid sequence is in complete...

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Veröffentlicht in:	FEBS letters 1993-11, Vol.334 (1), p.139-142
Hauptverfasser:	Klein, Jörg M., Mangerich, Sigrid, de Kleijn, Dominique P.V., Keller, Rainer, Weidemann, Wolfgang M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences Brachyura Carcinus maenas cDNA sequence CHH, crustacean hyperglycemic hormone Cloning, Molecular CPRP, CHH precursor related peptide Crustacea DNA Fundamental and applied biological sciences. Psychology Genes. Genome GIH (=VIH), gonad-inhibiting hormone (vitellogenesis-inhibiting hormone) Invertebrate Hormones - chemistry Invertebrate Hormones - genetics Marine MIH, molt-inhibiting hormone Molecular and cellular biology Molecular genetics Molecular Sequence Data Molt-inhibiting hormone MTXO, medulla terminalis X-organ Neuropeptide precursor PCR, polymerase chain reaction Polymerase Chain Reaction Protein Precursors - chemistry Protein Precursors - genetics SG, sinus gland SP, signal peptide
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Beschreibung
Zusammenfassung:	A cDNA encoding the complete precursor of the putative molt-inhibiting hormone (MIH) of the shore crab, Carcinus maenas, was isolated and sequenced. The precursor consists of a putative 35 amino acid signal peptide and the 78 amino acid mature MIH. The deduced MIH amino acid sequence is in complete agreement with the sequence previously determined by Edman degradation. In situ hybridization revealed MIH-expression in a subpopulation of large neurosecretory perikarya of the medulla terminalis X-organ in the eyestalk.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(93)81699-Z