Partial characteristics of an analog of pyridinoline isolated from human skin

The most abundant amine in acid hydrolysates of human skin, eluting in the crosslink region of a reversed-phase HPLC chromatogram, has the same retention time as pyridinoline standard. This amine is not pyridinoline, since it is a weak fluorophore and its U/V spectrum does not agree with that of pyr...

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Veröffentlicht in:	Biochemical and biophysical research communications 1985-02, Vol.126 (3), p.1222-1227
Hauptverfasser:	Tilson, M D, Dreyer, R N, Hudson, A, Cotter, R J, Tanzer, M L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - isolation & purification Amino Acids - isolation & purification Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Humans Marfan Syndrome - metabolism Mass Spectrometry Skin - analysis
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Zusammenfassung:	The most abundant amine in acid hydrolysates of human skin, eluting in the crosslink region of a reversed-phase HPLC chromatogram, has the same retention time as pyridinoline standard. This amine is not pyridinoline, since it is a weak fluorophore and its U/V spectrum does not agree with that of pyridinoline. The unknown amine was isolated and characterized by fast atom bombardment mass spectrometry and its structure is consistent with a deoxy-analogue of pyridinoline. It may be a crosslink component of some biological importance, since it is not detectable in skin from a patient with Marfan's Syndrome.
ISSN:	0006-291X