A Second Glucagon in the Pancreatic Islets of the Daddy Sculpin Cottus scorpius

The peptide hormone glucagon has been isolated from the islet tissue (Brockmann bodies) of the teleost Cottus scorpius (daddy sculpin) and sequenced. The sequence is HSEGTSNDYSKYLEDRKAQDFVQWLMNN differing at four positions from the glucagon found earlier in the same species by Conlon and coworkers (...

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Veröffentlicht in:	General and comparative endocrinology 1993-09, Vol.91 (3), p.281-286
Hauptverfasser:	Cutfield, Susan M., Cutfield, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, Gel Chromatography, High Pressure Liquid Cottus scorpius Fishes - physiology Fundamental and applied biological sciences. Psychology Glucagon - metabolism Islets of Langerhans - metabolism Marine Molecular Sequence Data Phylogeny Proteins Species Specificity
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Beschreibung
Zusammenfassung:	The peptide hormone glucagon has been isolated from the islet tissue (Brockmann bodies) of the teleost Cottus scorpius (daddy sculpin) and sequenced. The sequence is HSEGTSNDYSKYLEDRKAQDFVQWLMNN differing at four positions from the glucagon found earlier in the same species by Conlon and coworkers (1987b, Eur. J. Biochem, 164, 117-122). Thus sculpin, in common with anglerfish, possesses two distinct glucagons. Comparative sequence data are presented as a phylogenetic tree.
ISSN:	0016-6480 1095-6840
DOI:	10.1006/gcen.1993.1128