Human papillomavirus DNA in aerodigestive squamous carcinomas demonstrated by means of in situ hybridisation
A series of 10 oesophageal and 10 laryngeal squamous carcinomas was examined by means of immunocytochemistry and in situ DNA hybridisation to demonstrate human papillomavirus (HPV) infection. Changes in the epithelium adjacent to the carcinoma were found in 5 of 10 oesophageal and 7 of 10 laryngeal...
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| Veröffentlicht in: | South African Medical Journal/Suid-Afrikaanse Mediese Tydskrift 1993-07, Vol.83 (7), p.516-518 |
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| container_title | South African Medical Journal/Suid-Afrikaanse Mediese Tydskrift |
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| creator | VAN RENSBURG, E. J VENTER, E. H SIMSON, I. W |
| description | A series of 10 oesophageal and 10 laryngeal squamous carcinomas was examined by means of immunocytochemistry and in situ DNA hybridisation to demonstrate human papillomavirus (HPV) infection. Changes in the epithelium adjacent to the carcinoma were found in 5 of 10 oesophageal and 7 of 10 laryngeal carcinomas. Viral antigens could not be detected with immunocytochemistry in any of the specimens. HPV 6, 11 and 16 were detected in 3 oesophageal specimens. In one of these, HPV 16 was detected in normal as well as malignant cells. HPV 7 was detected for the first time in a laryngeal carcinoma. Our results confirm previous reports of possible HPV involvement in the pathogenesis of aerodigestive carcinomas. |
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J ; VENTER, E. H ; SIMSON, I. W</creator><creatorcontrib>VAN RENSBURG, E. J ; VENTER, E. H ; SIMSON, I. W</creatorcontrib><description>A series of 10 oesophageal and 10 laryngeal squamous carcinomas was examined by means of immunocytochemistry and in situ DNA hybridisation to demonstrate human papillomavirus (HPV) infection. Changes in the epithelium adjacent to the carcinoma were found in 5 of 10 oesophageal and 7 of 10 laryngeal carcinomas. Viral antigens could not be detected with immunocytochemistry in any of the specimens. HPV 6, 11 and 16 were detected in 3 oesophageal specimens. In one of these, HPV 16 was detected in normal as well as malignant cells. HPV 7 was detected for the first time in a laryngeal carcinoma. Our results confirm previous reports of possible HPV involvement in the pathogenesis of aerodigestive carcinomas.</description><identifier>ISSN: 0256-9574</identifier><identifier>ISSN: 0038-2469</identifier><identifier>PMID: 8211495</identifier><identifier>CODEN: SAMJAF</identifier><language>eng</language><publisher>Pinelands: Medical Association of South Africa</publisher><subject>Biological and medical sciences ; Biopsy ; Carcinoma, Squamous Cell - microbiology ; DNA Probes, HPV ; DNA, Viral - analysis ; Esophageal Neoplasms - microbiology ; Esophagus ; Gastroenterology. Liver. Pancreas. 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J</creatorcontrib><creatorcontrib>VENTER, E. H</creatorcontrib><creatorcontrib>SIMSON, I. W</creatorcontrib><title>Human papillomavirus DNA in aerodigestive squamous carcinomas demonstrated by means of in situ hybridisation</title><title>South African Medical Journal/Suid-Afrikaanse Mediese Tydskrift</title><addtitle>S Afr Med J</addtitle><description>A series of 10 oesophageal and 10 laryngeal squamous carcinomas was examined by means of immunocytochemistry and in situ DNA hybridisation to demonstrate human papillomavirus (HPV) infection. Changes in the epithelium adjacent to the carcinoma were found in 5 of 10 oesophageal and 7 of 10 laryngeal carcinomas. Viral antigens could not be detected with immunocytochemistry in any of the specimens. HPV 6, 11 and 16 were detected in 3 oesophageal specimens. In one of these, HPV 16 was detected in normal as well as malignant cells. HPV 7 was detected for the first time in a laryngeal carcinoma. Our results confirm previous reports of possible HPV involvement in the pathogenesis of aerodigestive carcinomas.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Carcinoma, Squamous Cell - microbiology</subject><subject>DNA Probes, HPV</subject><subject>DNA, Viral - analysis</subject><subject>Esophageal Neoplasms - microbiology</subject><subject>Esophagus</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>In Situ Hybridization</subject><subject>Laryngeal Neoplasms - microbiology</subject><subject>Medical sciences</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Tropical medicine</subject><subject>Tumors</subject><issn>0256-9574</issn><issn>0038-2469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OwzAQhHMAlVJ4BCQfELdKsWM7ybEqP0Wq4ALnaGOvwSh2Ujup1LfHiIgrp9Vqvl3NzFm2zJmQ61qU_CK7jPErT7uo5SJbVIxSXotl1u0mB54MMNiu6x0cbZgiuX_ZEOsJYOi1_cA42iOSeJjA9UlVEJT1CY5Eo-t9HAOMqEl7Ig7BR9Kbn-tox4l8ntpgtY0w2t5fZecGuojX81xl748Pb9vdev_69Lzd7NcDk3JcF6bWZV5gyzhIEEbVgEXNjC5UC7nRZatzrFiFoqYFN4XQmrKWIhdMVSUTxSq7-_07hP4wJfuNs1Fh14HHFKApZSqiouW_IJUl5yyvEngzg1PrUDdDsA7CqZl7TPrtrENU0JkAXtn4h_FKcprMfgNYiXza</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>VAN RENSBURG, E. 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W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human papillomavirus DNA in aerodigestive squamous carcinomas demonstrated by means of in situ hybridisation</atitle><jtitle>South African Medical Journal/Suid-Afrikaanse Mediese Tydskrift</jtitle><addtitle>S Afr Med J</addtitle><date>1993-07-01</date><risdate>1993</risdate><volume>83</volume><issue>7</issue><spage>516</spage><epage>518</epage><pages>516-518</pages><issn>0256-9574</issn><issn>0038-2469</issn><coden>SAMJAF</coden><abstract>A series of 10 oesophageal and 10 laryngeal squamous carcinomas was examined by means of immunocytochemistry and in situ DNA hybridisation to demonstrate human papillomavirus (HPV) infection. Changes in the epithelium adjacent to the carcinoma were found in 5 of 10 oesophageal and 7 of 10 laryngeal carcinomas. Viral antigens could not be detected with immunocytochemistry in any of the specimens. HPV 6, 11 and 16 were detected in 3 oesophageal specimens. 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| identifier | ISSN: 0256-9574 |
| ispartof | South African Medical Journal/Suid-Afrikaanse Mediese Tydskrift, 1993-07, Vol.83 (7), p.516-518 |
| issn | 0256-9574 0038-2469 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Biopsy Carcinoma, Squamous Cell - microbiology DNA Probes, HPV DNA, Viral - analysis Esophageal Neoplasms - microbiology Esophagus Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques In Situ Hybridization Laryngeal Neoplasms - microbiology Medical sciences Papillomaviridae - isolation & purification Tropical medicine Tumors |
| title | Human papillomavirus DNA in aerodigestive squamous carcinomas demonstrated by means of in situ hybridisation |
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