Human papillomavirus DNA in aerodigestive squamous carcinomas demonstrated by means of in situ hybridisation

A series of 10 oesophageal and 10 laryngeal squamous carcinomas was examined by means of immunocytochemistry and in situ DNA hybridisation to demonstrate human papillomavirus (HPV) infection. Changes in the epithelium adjacent to the carcinoma were found in 5 of 10 oesophageal and 7 of 10 laryngeal...

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Veröffentlicht in:	South African Medical Journal/Suid-Afrikaanse Mediese Tydskrift 1993-07, Vol.83 (7), p.516-518
Hauptverfasser:	VAN RENSBURG, E. J, VENTER, E. H, SIMSON, I. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biopsy Carcinoma, Squamous Cell - microbiology DNA Probes, HPV DNA, Viral - analysis Esophageal Neoplasms - microbiology Esophagus Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques In Situ Hybridization Laryngeal Neoplasms - microbiology Medical sciences Papillomaviridae - isolation & purification Tropical medicine Tumors
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Beschreibung
Zusammenfassung:	A series of 10 oesophageal and 10 laryngeal squamous carcinomas was examined by means of immunocytochemistry and in situ DNA hybridisation to demonstrate human papillomavirus (HPV) infection. Changes in the epithelium adjacent to the carcinoma were found in 5 of 10 oesophageal and 7 of 10 laryngeal carcinomas. Viral antigens could not be detected with immunocytochemistry in any of the specimens. HPV 6, 11 and 16 were detected in 3 oesophageal specimens. In one of these, HPV 16 was detected in normal as well as malignant cells. HPV 7 was detected for the first time in a laryngeal carcinoma. Our results confirm previous reports of possible HPV involvement in the pathogenesis of aerodigestive carcinomas.
ISSN:	0256-9574 0038-2469