Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 1985-02, Vol.313 (6005), p.756-761
Hauptverfasser:	Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L. M., Dull, T. J., Gray, A., Coussens, L., Liao, Y.-C., Tsubokawa, M., Mason, A., Seeburg, P. H., Grunfeld, C., Rosen, O. M., Ramachandran, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biological and medical sciences cDNA Cell physiology DNA - genetics ErbB Receptors Fundamental and applied biological sciences. Psychology gene products Genes Hormonal regulation Humanities and Social Sciences Humans insulin man Membrane Proteins - genetics Molecular and cellular biology Molecular Weight multidisciplinary nucleotide sequence Oncogenes Protein Conformation Protein Kinases - genetics Protein-Tyrosine Kinases Receptor, Insulin - genetics Receptors, Cell Surface - genetics RNA, Messenger - genetics Science Science (multidisciplinary)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/313756a0