Metabolism and pharmacokinetics of deuterium-labelled di-2-(ethylhexyl) adipate (DEHA) in humans

The metabolism and pharmacokinetics of [ 2H 10]di-2-(ethylhexyl) adipate (DEHA) labeled on the ethyl side-chains was determined in six male volunteers. The dose administered was 46 mg [ 2H 10]DEHA given orally. No parent molecule was found in plasma; however, the metabolite [ 2H 5]2-ethylhexanoic acid (EHA) was detected (mean rate of formation : 1.63 ± 1.19/hr; mean rate of elimination: 0.42 ± 0.1/hr. Further oxidative metabolism products were detected in urine; the dominant metabolite identified was EHA present as a conjugate and accounted for an average of 8.6% of the administered dose. [ 2H 5]2-Ethyl-5-hydroxyhexanoic acid, [ 2H 5]2-ethylhexanedioic acid, [ 2H 5]2-ethyl-5-keto-hexanoic acid and [ 2H 5]2-ethylhexanol together accounted for a further 3.5% of the dose. The fate of the remainder was not determined.