Effects of Chemotherapeutic Agents on the Immune Response. II
The antimetabolites consist of such agents as the purine and pyrimidine analogs and the antifolates, which inhibit the synthesis of RNA, DNA, and protein. Two highly immunosuppressive antimetabolites that deserve special attention are the thiopurines: 6-mercaptopurine (6-MP) and azathioprime (Imuran...
Gespeichert in:
| Veröffentlicht in: | Cancer investigation 1985, Vol.3 (1), p.23-33 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 33 |
|---|---|
| container_issue | 1 |
| container_start_page | 23 |
| container_title | Cancer investigation |
| container_volume | 3 |
| creator | Kempf, Raymond A. Mitchell, Malcolm S. |
| description | The antimetabolites consist of such agents as the purine and pyrimidine analogs and the antifolates, which inhibit the synthesis of RNA, DNA, and protein. Two highly immunosuppressive antimetabolites that deserve special attention are the thiopurines: 6-mercaptopurine (6-MP) and azathioprime (Imuran, AZA). The former has been used mostly for the chemotherapy of acute leukemias while the latter is used extensively in organ transplantation. The immunosuppressive properties of this group of agents has been extensively reviewed. |
| doi_str_mv | 10.3109/07357908509040605 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76002498</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76002498</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-5648c2519b6b12c612abb125c9ae3788fbd8365dc80ef641be83025541ff791c3</originalsourceid><addsrcrecordid>eNqFkFFLwzAUhYMoc05_gA9Cn3zrTNKkTVAfxpg6GAiizyVNb2ylbWrSIvv3tmwIIurTvdzvnMPlIHRO8DwiWF7hJOKJxIJjiRmOMT9AU8IjGjIi6SGajjwcBMkxOvH-DWMiaMInaEJ5IgSXU3S7MgZ05wNrgmUBte0KcKqFvit1sHiFZkRNMFyDdV33DQRP4FvbeJgH6_UpOjKq8nC2nzP0crd6Xj6Em8f79XKxCXXEki7kMROaciKzOCNUx4SqbFi4lgqi4RGT5SKKea4FBhMzkoGIMOWcEWMSSXQ0Q5e73NbZ9x58l9al11BVqgHb-zSJMaZMin-FhFHMOGWDkOyE2lnvHZi0dWWt3DYlOB27TX90O3gu9uF9VkP-5diXOfCbHS8bY12tPqyr8rRT28o641SjSz9G_x5__c1egKq6QisH6ZvtXTMU_Mdzn92Wlzg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14204524</pqid></control><display><type>article</type><title>Effects of Chemotherapeutic Agents on the Immune Response. II</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Taylor & Francis Journals Complete</source><creator>Kempf, Raymond A. ; Mitchell, Malcolm S.</creator><creatorcontrib>Kempf, Raymond A. ; Mitchell, Malcolm S.</creatorcontrib><description>The antimetabolites consist of such agents as the purine and pyrimidine analogs and the antifolates, which inhibit the synthesis of RNA, DNA, and protein. Two highly immunosuppressive antimetabolites that deserve special attention are the thiopurines: 6-mercaptopurine (6-MP) and azathioprime (Imuran, AZA). The former has been used mostly for the chemotherapy of acute leukemias while the latter is used extensively in organ transplantation. The immunosuppressive properties of this group of agents has been extensively reviewed.</description><identifier>ISSN: 0735-7907</identifier><identifier>EISSN: 1532-4192</identifier><identifier>DOI: 10.3109/07357908509040605</identifier><identifier>PMID: 2578859</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adrenal Cortex Hormones - pharmacology ; Animals ; Antibiotics, Antineoplastic ; Antineoplastic Agents - pharmacology ; Asparaginase - pharmacology ; Bleomycin - pharmacology ; Cyclosporins - pharmacology ; Cytarabine - pharmacology ; Fluorouracil - pharmacology ; Humans ; Immunity - drug effects ; Interferons - pharmacology ; Mercaptopurine - pharmacology ; Methotrexate - pharmacology ; Naphthacenes - pharmacology</subject><ispartof>Cancer investigation, 1985, Vol.3 (1), p.23-33</ispartof><rights>1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1985</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-5648c2519b6b12c612abb125c9ae3788fbd8365dc80ef641be83025541ff791c3</citedby><cites>FETCH-LOGICAL-c347t-5648c2519b6b12c612abb125c9ae3788fbd8365dc80ef641be83025541ff791c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/07357908509040605$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/07357908509040605$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2578859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kempf, Raymond A.</creatorcontrib><creatorcontrib>Mitchell, Malcolm S.</creatorcontrib><title>Effects of Chemotherapeutic Agents on the Immune Response. II</title><title>Cancer investigation</title><addtitle>Cancer Invest</addtitle><description>The antimetabolites consist of such agents as the purine and pyrimidine analogs and the antifolates, which inhibit the synthesis of RNA, DNA, and protein. Two highly immunosuppressive antimetabolites that deserve special attention are the thiopurines: 6-mercaptopurine (6-MP) and azathioprime (Imuran, AZA). The former has been used mostly for the chemotherapy of acute leukemias while the latter is used extensively in organ transplantation. The immunosuppressive properties of this group of agents has been extensively reviewed.</description><subject>Adrenal Cortex Hormones - pharmacology</subject><subject>Animals</subject><subject>Antibiotics, Antineoplastic</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Asparaginase - pharmacology</subject><subject>Bleomycin - pharmacology</subject><subject>Cyclosporins - pharmacology</subject><subject>Cytarabine - pharmacology</subject><subject>Fluorouracil - pharmacology</subject><subject>Humans</subject><subject>Immunity - drug effects</subject><subject>Interferons - pharmacology</subject><subject>Mercaptopurine - pharmacology</subject><subject>Methotrexate - pharmacology</subject><subject>Naphthacenes - pharmacology</subject><issn>0735-7907</issn><issn>1532-4192</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFFLwzAUhYMoc05_gA9Cn3zrTNKkTVAfxpg6GAiizyVNb2ylbWrSIvv3tmwIIurTvdzvnMPlIHRO8DwiWF7hJOKJxIJjiRmOMT9AU8IjGjIi6SGajjwcBMkxOvH-DWMiaMInaEJ5IgSXU3S7MgZ05wNrgmUBte0KcKqFvit1sHiFZkRNMFyDdV33DQRP4FvbeJgH6_UpOjKq8nC2nzP0crd6Xj6Em8f79XKxCXXEki7kMROaciKzOCNUx4SqbFi4lgqi4RGT5SKKea4FBhMzkoGIMOWcEWMSSXQ0Q5e73NbZ9x58l9al11BVqgHb-zSJMaZMin-FhFHMOGWDkOyE2lnvHZi0dWWt3DYlOB27TX90O3gu9uF9VkP-5diXOfCbHS8bY12tPqyr8rRT28o641SjSz9G_x5__c1egKq6QisH6ZvtXTMU_Mdzn92Wlzg</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Kempf, Raymond A.</creator><creator>Mitchell, Malcolm S.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Effects of Chemotherapeutic Agents on the Immune Response. II</title><author>Kempf, Raymond A. ; Mitchell, Malcolm S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-5648c2519b6b12c612abb125c9ae3788fbd8365dc80ef641be83025541ff791c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adrenal Cortex Hormones - pharmacology</topic><topic>Animals</topic><topic>Antibiotics, Antineoplastic</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Asparaginase - pharmacology</topic><topic>Bleomycin - pharmacology</topic><topic>Cyclosporins - pharmacology</topic><topic>Cytarabine - pharmacology</topic><topic>Fluorouracil - pharmacology</topic><topic>Humans</topic><topic>Immunity - drug effects</topic><topic>Interferons - pharmacology</topic><topic>Mercaptopurine - pharmacology</topic><topic>Methotrexate - pharmacology</topic><topic>Naphthacenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kempf, Raymond A.</creatorcontrib><creatorcontrib>Mitchell, Malcolm S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kempf, Raymond A.</au><au>Mitchell, Malcolm S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Chemotherapeutic Agents on the Immune Response. II</atitle><jtitle>Cancer investigation</jtitle><addtitle>Cancer Invest</addtitle><date>1985</date><risdate>1985</risdate><volume>3</volume><issue>1</issue><spage>23</spage><epage>33</epage><pages>23-33</pages><issn>0735-7907</issn><eissn>1532-4192</eissn><abstract>The antimetabolites consist of such agents as the purine and pyrimidine analogs and the antifolates, which inhibit the synthesis of RNA, DNA, and protein. Two highly immunosuppressive antimetabolites that deserve special attention are the thiopurines: 6-mercaptopurine (6-MP) and azathioprime (Imuran, AZA). The former has been used mostly for the chemotherapy of acute leukemias while the latter is used extensively in organ transplantation. The immunosuppressive properties of this group of agents has been extensively reviewed.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>2578859</pmid><doi>10.3109/07357908509040605</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-7907 |
| ispartof | Cancer investigation, 1985, Vol.3 (1), p.23-33 |
| issn | 0735-7907 1532-4192 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76002498 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adrenal Cortex Hormones - pharmacology Animals Antibiotics, Antineoplastic Antineoplastic Agents - pharmacology Asparaginase - pharmacology Bleomycin - pharmacology Cyclosporins - pharmacology Cytarabine - pharmacology Fluorouracil - pharmacology Humans Immunity - drug effects Interferons - pharmacology Mercaptopurine - pharmacology Methotrexate - pharmacology Naphthacenes - pharmacology |
| title | Effects of Chemotherapeutic Agents on the Immune Response. II |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T06%3A40%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Chemotherapeutic%20Agents%20on%20the%20Immune%20Response.%20II&rft.jtitle=Cancer%20investigation&rft.au=Kempf,%20Raymond%20A.&rft.date=1985&rft.volume=3&rft.issue=1&rft.spage=23&rft.epage=33&rft.pages=23-33&rft.issn=0735-7907&rft.eissn=1532-4192&rft_id=info:doi/10.3109/07357908509040605&rft_dat=%3Cproquest_cross%3E76002498%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14204524&rft_id=info:pmid/2578859&rfr_iscdi=true |