Effects of Chemotherapeutic Agents on the Immune Response. II

The antimetabolites consist of such agents as the purine and pyrimidine analogs and the antifolates, which inhibit the synthesis of RNA, DNA, and protein. Two highly immunosuppressive antimetabolites that deserve special attention are the thiopurines: 6-mercaptopurine (6-MP) and azathioprime (Imuran...

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Veröffentlicht in:	Cancer investigation 1985, Vol.3 (1), p.23-33
Hauptverfasser:	Kempf, Raymond A., Mitchell, Malcolm S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - pharmacology Animals Antibiotics, Antineoplastic Antineoplastic Agents - pharmacology Asparaginase - pharmacology Bleomycin - pharmacology Cyclosporins - pharmacology Cytarabine - pharmacology Fluorouracil - pharmacology Humans Immunity - drug effects Interferons - pharmacology Mercaptopurine - pharmacology Methotrexate - pharmacology Naphthacenes - pharmacology
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Beschreibung
Zusammenfassung:	The antimetabolites consist of such agents as the purine and pyrimidine analogs and the antifolates, which inhibit the synthesis of RNA, DNA, and protein. Two highly immunosuppressive antimetabolites that deserve special attention are the thiopurines: 6-mercaptopurine (6-MP) and azathioprime (Imuran, AZA). The former has been used mostly for the chemotherapy of acute leukemias while the latter is used extensively in organ transplantation. The immunosuppressive properties of this group of agents has been extensively reviewed.
ISSN:	0735-7907 1532-4192
DOI:	10.3109/07357908509040605