ISOLATION AND CHARACTERIZATION OF BULGECINS, NEW BACTERIAL METABOLITES WITH BULGE-INDUCING ACTIVITY
Bulgecins A, B and C, new bacterial metabolites which induce the formation of bulges by cooperation with β-lactam antibiotics, were isolated from the culture broth of Pseudomonas mesoacidophila. The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic c...
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| Veröffentlicht in: | Journal of antibiotics 1985, Vol.38(1), pp.17-23 |
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| container_issue | 1 |
| container_start_page | 17 |
| container_title | Journal of antibiotics |
| container_volume | 38 |
| creator | SHINAGAWA, SUSUMU MAKI, MASANORI KINTAKA, KAZUHIKO IMADA, AKIRA ASAI, MITSUKO |
| description | Bulgecins A, B and C, new bacterial metabolites which induce the formation of bulges by cooperation with β-lactam antibiotics, were isolated from the culture broth of Pseudomonas mesoacidophila. The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic compounds containing a sulfate group in the molecule. Acid hydrolysis showed that D-glucosamine and a new proline derivative are common constituents of the three components. In addition, taurine and β-alanine are constituents of bulgecins A and B, respectively. |
| doi_str_mv | 10.7164/antibiotics.38.17 |
| format | Article |
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The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic compounds containing a sulfate group in the molecule. Acid hydrolysis showed that D-glucosamine and a new proline derivative are common constituents of the three components. In addition, taurine and β-alanine are constituents of bulgecins A and B, respectively.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.38.17</identifier><identifier>PMID: 3918981</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>beta -lactam antibiotics ; beta-Alanine - analysis ; bulgecins ; Glucosamine - analysis ; Glycopeptides - isolation & purification ; Hydrolysis ; Proline - analogs & derivatives ; Proline - analysis ; Pseudomonas - analysis ; Pseudomonas mesoacidophila ; Solubility ; Spectrum Analysis</subject><ispartof>The Journal of Antibiotics, 1985, Vol.38(1), pp.17-23</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-776a0d9c36f595848d620e84cd279089897f9ef21a6f4e42e8df4f2b1f0292cf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3918981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHINAGAWA, SUSUMU</creatorcontrib><creatorcontrib>MAKI, MASANORI</creatorcontrib><creatorcontrib>KINTAKA, KAZUHIKO</creatorcontrib><creatorcontrib>IMADA, AKIRA</creatorcontrib><creatorcontrib>ASAI, MITSUKO</creatorcontrib><title>ISOLATION AND CHARACTERIZATION OF BULGECINS, NEW BACTERIAL METABOLITES WITH BULGE-INDUCING ACTIVITY</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Bulgecins A, B and C, new bacterial metabolites which induce the formation of bulges by cooperation with β-lactam antibiotics, were isolated from the culture broth of Pseudomonas mesoacidophila. The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic compounds containing a sulfate group in the molecule. Acid hydrolysis showed that D-glucosamine and a new proline derivative are common constituents of the three components. 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Antibiot.</addtitle><date>1985</date><risdate>1985</risdate><volume>38</volume><issue>1</issue><spage>17</spage><epage>23</epage><pages>17-23</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>Bulgecins A, B and C, new bacterial metabolites which induce the formation of bulges by cooperation with β-lactam antibiotics, were isolated from the culture broth of Pseudomonas mesoacidophila. The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic compounds containing a sulfate group in the molecule. Acid hydrolysis showed that D-glucosamine and a new proline derivative are common constituents of the three components. In addition, taurine and β-alanine are constituents of bulgecins A and B, respectively.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>3918981</pmid><doi>10.7164/antibiotics.38.17</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1985, Vol.38(1), pp.17-23 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76001839 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | beta -lactam antibiotics beta-Alanine - analysis bulgecins Glucosamine - analysis Glycopeptides - isolation & purification Hydrolysis Proline - analogs & derivatives Proline - analysis Pseudomonas - analysis Pseudomonas mesoacidophila Solubility Spectrum Analysis |
| title | ISOLATION AND CHARACTERIZATION OF BULGECINS, NEW BACTERIAL METABOLITES WITH BULGE-INDUCING ACTIVITY |
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