ISOLATION AND CHARACTERIZATION OF BULGECINS, NEW BACTERIAL METABOLITES WITH BULGE-INDUCING ACTIVITY

ISOLATION AND CHARACTERIZATION OF BULGECINS, NEW BACTERIAL METABOLITES WITH BULGE-INDUCING ACTIVITY

Bulgecins A, B and C, new bacterial metabolites which induce the formation of bulges by cooperation with β-lactam antibiotics, were isolated from the culture broth of Pseudomonas mesoacidophila. The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic c...

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Veröffentlicht in:Journal of antibiotics 1985, Vol.38(1), pp.17-23
Hauptverfasser: SHINAGAWA, SUSUMU, MAKI, MASANORI, KINTAKA, KAZUHIKO, IMADA, AKIRA, ASAI, MITSUKO
Format: Artikel
Sprache:eng
Schlagworte:
beta -lactam antibiotics
beta-Alanine - analysis
bulgecins
Glucosamine - analysis
Glycopeptides - isolation & purification
Hydrolysis
Proline - analogs & derivatives
Proline - analysis
Pseudomonas - analysis
Pseudomonas mesoacidophila
Solubility
Spectrum Analysis
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Zusammenfassung:Bulgecins A, B and C, new bacterial metabolites which induce the formation of bulges by cooperation with β-lactam antibiotics, were isolated from the culture broth of Pseudomonas mesoacidophila. The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic compounds containing a sulfate group in the molecule. Acid hydrolysis showed that D-glucosamine and a new proline derivative are common constituents of the three components. In addition, taurine and β-alanine are constituents of bulgecins A and B, respectively.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.38.17