Gadolinium-DTPA as a contrast agent in MR imaging―theoretical projections and practical observations

The theoretical basis for the use of paramagnetic agents to enhance proton relaxation is described. Factors of importance in the design of contrast agents are considered. Measurements of changes in T1 and T2 in vitro due to Gd3+-diethylenetriamine pentaacetic acid (DTPA) are used to predict changes...

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Veröffentlicht in:	Journal of computer assisted tomography 1985-01, Vol.9 (2), p.242-251
Hauptverfasser:	GADIAN, D. G, PAYNE, J. A, BRYANT, D. J, YOUNG, I. R, CARR, D. H, BYDDER, G. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Brain Neoplasms - diagnosis Carcinoid Tumor - diagnosis Ependymoma - diagnosis Exact sciences and technology Female Humans Magnetic Resonance Spectroscopy Other techniques and industries Pentetic Acid Vaginal Neoplasms - diagnosis
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Zusammenfassung:	The theoretical basis for the use of paramagnetic agents to enhance proton relaxation is described. Factors of importance in the design of contrast agents are considered. Measurements of changes in T1 and T2 in vitro due to Gd3+-diethylenetriamine pentaacetic acid (DTPA) are used to predict changes in the intensity of transverse magnetisation seen with different sequences in magnetic resonance imaging. The use of Gd3+-DTPA in clinical cases is illustrated.
ISSN:	0363-8715 1532-3145
DOI:	10.1097/00004728-198503000-00003