Production and response to interleukin 2 in vitro and in vivo after bone marrow transplantation in mice

Lymphoid cells from bone marrow radiation chimeras do not produce normal levels of IL 2 but are capable of responding to IL 2 in mitogenic and cytotoxic assays in vitro. The administration of recombinant human IL 2 into host mice that have received allogeneic, H-2-compatible marrow did not enhance m...

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Veröffentlicht in:	The Journal of immunology (1950) 1985-04, Vol.134 (4), p.2426-2430
Hauptverfasser:	Merluzzi, VJ, Welte, K, Last-Barney, K, Mertelsmann, R, Souza, L, Boone, T, Savage, DM, Quinn, D, O'Reilly, RJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Cell Line Cytotoxicity, Immunologic Disease Models, Animal Interleukin-2 - biosynthesis Interleukin-2 - physiology Lymphocyte Activation Male Mast-Cell Sarcoma - immunology Medical sciences Mice Mice, Inbred C3H Mice, Inbred CBA Mice, Inbred DBA Postoperative Complications Spleen - cytology T-Lymphocytes, Cytotoxic - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Zusammenfassung:	Lymphoid cells from bone marrow radiation chimeras do not produce normal levels of IL 2 but are capable of responding to IL 2 in mitogenic and cytotoxic assays in vitro. The administration of recombinant human IL 2 into host mice that have received allogeneic, H-2-compatible marrow did not enhance mortality.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.134.4.2426