Leukotrienes in the pathophysiology of kwashiorkor

Leukotrienes in the pathophysiology of kwashiorkor

Summary The actions of cysteinyl leukotrienes include production of oedema. We investigated whether these mediators might be involved in the oedematous malnutrition syndrome kwashiorkor. The capacity of leukotriene (LT) synthesis by stimulated whole blood and urinary LTE 4 excretion was measured in...

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Veröffentlicht in:The Lancet (British edition) 1993-10, Vol.342 (8877), p.958-960
Hauptverfasser: Mayatepek, E, Becker, K, Hoffmann, G.F, Leichsenring, M, Gana, L
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Blood
Child, Preschool
Disease
Edema - metabolism
Excretion
Glutathione - blood
Health Status
Humans
Immunity (Disease)
Infant
Kwashiorkor - metabolism
Kwashiorkor - physiopathology
Leukotriene E4 - biosynthesis
Leukotriene E4 - metabolism
Malnutrition
Medical research
Medical sciences
Metabolic diseases
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
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Zusammenfassung:Summary The actions of cysteinyl leukotrienes include production of oedema. We investigated whether these mediators might be involved in the oedematous malnutrition syndrome kwashiorkor. The capacity of leukotriene (LT) synthesis by stimulated whole blood and urinary LTE 4 excretion was measured in 12 children with kwashiorkor, and compared with that in 24 marasmic and 12 control children. Urinary LTE 4 excretion was significantly higher in patients with kwashiorkor than in controls (118·8 [SD 28 5] vs 31 1 [19·3] nmol/mol creatinine; p
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(93)92003-C