Insulin resistance, glucose intolerance, and hyperinsulinemia in patients with microvascular angina

Plasma glucose and insulin responses to oral glucose and insulin-mediated glucose disposal were determined in 20 patients with microvascular angina and 20 normal volunteers who were similar in terms of age, gender distribution, and degree of obesity. Plasma glucose and insulin responses to a 75-g oral glucose challenge were significantly higher in those with microvascular angina ( P < .001), as were steady-state plasma glucose concentrations after a 180-minute infusion of somatostatin, glucose, and insulin (12.2 ± 1.0 v 7.6 ± 0.6 mmol/L, P < .001). Since steady-state plasma insulin concentrations were similar in the two groups (627 ± 32 v 631 ± 29 pmol/L), these data indicate that patients with microvascular angina are insulin-resistant, glucose-intolerant, and hyperinsulinemic compared with a matched group of normal volunteers.