Inhibitors for distinction of three types of human glutathione transferase

A set of inhibitors that are useful for distinction of three types of human cytosolic glutathione transferase is presented. The near-neutral transferase is inhibited most effectively by Cibacron blue (itI 50 = 0.05 μM), the acidic transferase by Cibacron blue (itI 50 = 0.5 μM), and the basic transfe...

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Veröffentlicht in:	FEBS letters 1985-02, Vol.181 (2), p.249-252
Hauptverfasser:	Kalim Tahir, Mohammad, Guthenberg, Claes, Mannervik, Bengt
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Cibacron blue Cytosol - enzymology Discriminatory inhibitor Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology glutathione transferase Glutathione Transferase - antagonists & inhibitors Human glutathione transferase Humans Isoenzyme Isoenzymes - antagonists & inhibitors Liver - enzymology man Organotin compound Placenta - enzymology Pregnancy Transferases Trialkyltin Compounds - pharmacology Triazines - pharmacology
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Zusammenfassung:	A set of inhibitors that are useful for distinction of three types of human cytosolic glutathione transferase is presented. The near-neutral transferase is inhibited most effectively by Cibacron blue (itI 50 = 0.05 μM), the acidic transferase by Cibacron blue (itI 50 = 0.5 μM), and the basic transferase by tributyltin acetate (itI 50 = 0.1 μM). The use of any of these two compounds makes possible differentiation between all three types of human transferase.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(85)80269-6