Receptors for thymosin alpha 1 on mouse thymocytes

Thymosin α 1, is able to act in vitro to stimulate T-cell precursors and to induce surface markers. The initial mechanism by which α 1 activates T cells could be the binding of α 1 to cell membranes. Using a specific anti- α 1 antibody and an indirect immunofluorescence procedure it was found that t...

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Veröffentlicht in:	Cellular immunology 1985-01, Vol.91 (1), p.289-293
Hauptverfasser:	Garaci, Cristina Rinaldi, Torrisi, Maria Rosaria, Jezzi, Teresa, Frati, Luigi, Goldstein, Allan L., Garaci, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cell membranes Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Lectins Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Male Mice Mice, Inbred C57BL Peanut Agglutinin Phenotype receptors Receptors, Immunologic - analysis T-Lymphocytes - classification T-Lymphocytes - metabolism Thymalfasin thymocytes Thymosin - analogs & derivatives Thymosin - metabolism thymosin alpha 1
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Zusammenfassung:	Thymosin α 1, is able to act in vitro to stimulate T-cell precursors and to induce surface markers. The initial mechanism by which α 1 activates T cells could be the binding of α 1 to cell membranes. Using a specific anti- α 1 antibody and an indirect immunofluorescence procedure it was found that thymosin α 1 binds to the surface of a large portion of murine lymphocytes. Furthermore, thymocytes have been fractionated into immature and mature subpopulations by using the peanut agglutinin (PNA) technique. It was found that PNA +, immature cells showed specific receptors for α 1 on the cell membrane.
ISSN:	0008-8749 1090-2163
DOI:	10.1016/0008-8749(85)90051-6