Screening of sera and tumor extracts of cancer patients using a monoclonal antibody directed against human placental alkaline phosphatase

A sensitive endogenous enzyme immunoassay involving an anti-human placental alkaline phosphatase (PLAP) monoclonal antibody was used in the screening of sera and tumor extracts of patients with various types of cancer. In sera of breast cancer patients an incidence of 5.2% was recorded. This value r...

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Veröffentlicht in:	European journal of cancer & clinical oncology 1985, Vol.21 (1), p.65-71
Hauptverfasser:	Van de Voorde, Andre, De Groote, Guy, De Waele, Peter, De Broe, Mark E., Pollet, Dirk, De Boever, Jozef, Vandekerckhove, Dirk, Fiers, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alkaline Phosphatase - analysis Alkaline Phosphatase - blood Antibodies, Monoclonal Biological and medical sciences Breast Neoplasms - enzymology Female Host-tumor relations. Immunology. Biological markers Humans Immunoenzyme Techniques Isoenzymes - analysis Isoenzymes - blood Lung Neoplasms - enzymology Male Medical sciences Middle Aged Neoplasms - enzymology Ovarian Neoplasms - enzymology Tumors Uterine Neoplasms - enzymology
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Zusammenfassung:	A sensitive endogenous enzyme immunoassay involving an anti-human placental alkaline phosphatase (PLAP) monoclonal antibody was used in the screening of sera and tumor extracts of patients with various types of cancer. In sera of breast cancer patients an incidence of 5.2% was recorded. This value rose to 43% when tumor extracts were analyzed. For lung and bronchial cancers we found 11.2% seropositive patients. On several occasions a good correlation was observed between the PLAP determinations and the histopathological staging of tumor tissue.
ISSN:	0277-5379
DOI:	10.1016/0277-5379(85)90202-0