Variability of chromosomes 1, 9, and 16 in children with malignant diseases

Heterochromatic segments of chromosomes #1, #9, and #16 were analyzed in 38 children with malignant disease and 42 healthy persons. The analysis was carried out on C-banded metaphases obtained by peripheral blood culture. Using a quantitative method of analysis, an association was established betwee...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1985-03, Vol.16 (2), p.169-173
Hauptverfasser:	Petković, Iskra, Nakić, Melita, Čepulić, Mladen, Tiefenbach, Aleksandar, Konja, Josip
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Biological and medical sciences Child Child, Preschool Chromosome Aberrations Chromosome Banding Chromosomes, Human, 1-3 Chromosomes, Human, 16-18 Chromosomes, Human, 6-12 and X Female Humans Infant Karyotyping Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - blood Neoplasms - genetics Tumors
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Beschreibung
Zusammenfassung:	Heterochromatic segments of chromosomes #1, #9, and #16 were analyzed in 38 children with malignant disease and 42 healthy persons. The analysis was carried out on C-banded metaphases obtained by peripheral blood culture. Using a quantitative method of analysis, an association was established between C-segment length of chromosome #9 and malignant disease in children. A disturbed quantitative relation of C-heterochromatin of chromosomes #1, #9, and #16 was also found in the group of children with malignant disease.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(85)90011-1