9a, 11 -CYCLIC CARBAMATES OF 15-MEMBERED AZALIDES

The novel 9a, 11 -cyclic carbamates (13-15) of 9-deoxo-9a-aza-9a-homoerythromycin A (4) have been prepared and characterized by 1H-1H and 1H-13C 2D NMR spectroscopy. When compared to azithromycin (1) or its 6-O-methyl derivative (2), the new bicyclic 15-membered azalides exhibited substantially decr...

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Veröffentlicht in:	Journal of antibiotics 1993/08/25, Vol.46(8), pp.1239-1245
Hauptverfasser:	KOBREHEL, GABRIJELA, LAZAREVSKI, GORJANA, KELNERIC, ZELJKO, ÐOKIC, SLOBODAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Azithromycin - analogs & derivatives Azithromycin - chemistry Azithromycin - pharmacology Bacteria - drug effects Biological and medical sciences Erythromycin - analogs & derivatives Erythromycin - chemistry Erythromycin - pharmacology Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The novel 9a, 11 -cyclic carbamates (13-15) of 9-deoxo-9a-aza-9a-homoerythromycin A (4) have been prepared and characterized by 1H-1H and 1H-13C 2D NMR spectroscopy. When compared to azithromycin (1) or its 6-O-methyl derivative (2), the new bicyclic 15-membered azalides exhibited substantially decreased antibacterial activities in vitro.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.46.1239