Modifications of CFU-S differentiation pathways by pluripoietins: Influence of treatment protocols

Similar total doses of Ara-C given as a single injection or given in a fractionated protocol have reverse effects on CFU-S differentiation pathways. Whereas a single dose of 20 mg channels CFU-S towards erythropoiesis, 5 × 5 mg given at 8 or 24 hour intervals channels CFU-S to granulopoiesis and meg...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1985-02, Vol.11 (2), p.277-284
Hauptverfasser:	Lauret, Evelyne, Vendrely, Colette, Frindel, Emilia
Format:	Artikel
Sprache:	eng
Schlagworte:	560152 - Radiation Effects on Animals- Animals ALDEHYDES AMINES ANIMAL CELLS ANIMALS Antineoplastic agents Ara-C AZINES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BONE MARROW CELLS CELL DIFFERENTIATION Cell Differentiation - drug effects CFU CFU-S COBALT 60 COBALT ISOTOPES CONNECTIVE TISSUE CELLS Cytarabine - administration & dosage Cytarabine - pharmacology CYTOSINE Differentiation ELECTROMAGNETIC RADIATION Erythropoiesis - drug effects GAMMA RADIATION General aspects Hematopoietic Stem Cells - drug effects HETEROCYCLIC COMPOUNDS INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES IONIZING RADIATIONS IRRADIATION ISOMERIC TRANSITION ISOTOPES ISOTOPES LETHAL IRRADIATION MAMMALS Medical sciences MICE Mice, Inbred CBA MINUTES LIVING RADIOISOTOPES NUCLEI ODD-ODD NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS Pharmacology. Drug treatments Pluripoietins PYRIMIDINES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOISOTOPES RODENTS SOMATIC CELLS Specific Pathogen-Free Organisms SPLEEN CELLS VERTEBRATES YEARS LIVING RADIOISOTOPES
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Similar total doses of Ara-C given as a single injection or given in a fractionated protocol have reverse effects on CFU-S differentiation pathways. Whereas a single dose of 20 mg channels CFU-S towards erythropoiesis, 5 × 5 mg given at 8 or 24 hour intervals channels CFU-S to granulopoiesis and megakaryocytopoiesis. It therefore seems possible to manipulate CFU-S differentiation not only by varying the inducing agents but also by varying the protocols using the same agent. Hypotheses to explain the mechanisms of CFU-S regulation are presented.
ISSN:	0360-3016 1879-355X
DOI:	10.1016/0360-3016(85)90150-6