Malignant lymphoma in the donor heart after heart transplantation

A case of post-transplant lymphoproliferative disease (PTLD) with donor heart involvement is reported. The 49-year-old patient presented with heart failure initially ascribed to acute graft rejection. The treatment with high doses of immunosuppressive agents was unsuccessful and the outcome rapidly...

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Veröffentlicht in:	European heart journal 1993-08, Vol.14 (8), p.1143-1145
Hauptverfasser:	BURTIN, P, GUERCI, A, BOMAN, F, DOPFF, C, PINELLI, G, HABERER, J. P, VILLEMOT, J. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biopsy Cardiomyopathy, Dilated - pathology Cardiomyopathy, Dilated - surgery Diagnosis, Differential Graft Rejection - pathology Heart Neoplasms - pathology Heart Transplantation - pathology Hemodynamics - physiology Humans Immunoglobulin kappa-Chains - analysis Immunoglobulin Light Chains - analysis Immunoglobulin M - analysis Lymphoma, B-Cell - pathology Lymphoma, Non-Hodgkin - pathology Male Medical sciences Middle Aged Myocardium - pathology Postoperative Complications - pathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart
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Beschreibung
Zusammenfassung:	A case of post-transplant lymphoproliferative disease (PTLD) with donor heart involvement is reported. The 49-year-old patient presented with heart failure initially ascribed to acute graft rejection. The treatment with high doses of immunosuppressive agents was unsuccessful and the outcome rapidly fatal. This case suggests that cardiac failure occurring after high doses of immunosuppressive therapy could be a sign of early PTLD in heart transplant recipients.
ISSN:	0195-668X 1522-9645
DOI:	10.1093/eurheartj/14.8.1143