Chikungunya virus-associated death in Malaysia
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which causes fever, rash, and arthralgia. In the past, life-threatening complications were very rarely reported. However, during the recent worldwide outbreaks, there have been several reports of unusually severe complications and deaths. Mala...
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| Veröffentlicht in: | Tropical biomedicine 2010-08, Vol.27 (2), p.343-347 |
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| container_title | Tropical biomedicine |
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| creator | Sam, I C Kamarulzaman, A Ong, G S Y Veriah, R S Ponnampalavanar, S Chan, Y F AbuBakar, S |
| description | Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which causes fever, rash, and arthralgia. In the past, life-threatening complications were very rarely reported. However, during the recent worldwide outbreaks, there have been several reports of unusually severe complications and deaths. Malaysia is experiencing a nationwide outbreak of CHIKV, with over 10 000 patients affected since April 2008. We report the first case of culture-confirmed CHIKV-associated death in Malaysia, in a patient with fever, rash, acute exacerbation of pre-existing heart failure, rhabdomyolysis, and multiple organ failure. CHIKV infections may cause atypical, severe or fatal presentations. |
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In the past, life-threatening complications were very rarely reported. However, during the recent worldwide outbreaks, there have been several reports of unusually severe complications and deaths. Malaysia is experiencing a nationwide outbreak of CHIKV, with over 10 000 patients affected since April 2008. We report the first case of culture-confirmed CHIKV-associated death in Malaysia, in a patient with fever, rash, acute exacerbation of pre-existing heart failure, rhabdomyolysis, and multiple organ failure. 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CHIKV infections may cause atypical, severe or fatal presentations.</description><subject>Alphavirus Infections - epidemiology</subject><subject>Chikungunya Fever</subject><subject>Chikungunya virus - genetics</subject><subject>Fatal Outcome</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phylogeny</subject><issn>0127-5720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tKxDAUQLNQnHH0F6Q7V5Wbm6ZJllJ8wYgbXZfbJHWifdk0Qv9ewXF1NocD54RtgaPKpULYsPMYPwBkoXVxxjYIpkQl5JbdVIfwmYb3NKyUfYc5xZxiHG2gxbvMeVoOWRiyZ-pojYEu2GlLXfSXR-7Y2_3da_WY718enqrbfT4hhyVHarDgVigBUnPCBjlqajmBE4TC6sa2TgkNhiM6S4DeKGlL0EZQ01qxY9d_3Wkev5KPS92HaH3X0eDHFGsljVYlIv81r45manrv6mkOPc1r_b8ofgBPiEsQ</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Sam, I C</creator><creator>Kamarulzaman, A</creator><creator>Ong, G S Y</creator><creator>Veriah, R S</creator><creator>Ponnampalavanar, S</creator><creator>Chan, Y F</creator><creator>AbuBakar, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>Chikungunya virus-associated death in Malaysia</title><author>Sam, I C ; Kamarulzaman, A ; Ong, G S Y ; Veriah, R S ; Ponnampalavanar, S ; Chan, Y F ; AbuBakar, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p210t-2ab241c3730581a2b2128af1a0d3a23c8bcfd73809122dca02e975c60893abfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Alphavirus Infections - epidemiology</topic><topic>Chikungunya Fever</topic><topic>Chikungunya virus - genetics</topic><topic>Fatal Outcome</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phylogeny</topic><toplevel>online_resources</toplevel><creatorcontrib>Sam, I C</creatorcontrib><creatorcontrib>Kamarulzaman, A</creatorcontrib><creatorcontrib>Ong, G S Y</creatorcontrib><creatorcontrib>Veriah, R S</creatorcontrib><creatorcontrib>Ponnampalavanar, S</creatorcontrib><creatorcontrib>Chan, Y F</creatorcontrib><creatorcontrib>AbuBakar, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Tropical biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sam, I C</au><au>Kamarulzaman, A</au><au>Ong, G S Y</au><au>Veriah, R S</au><au>Ponnampalavanar, S</au><au>Chan, Y F</au><au>AbuBakar, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chikungunya virus-associated death in Malaysia</atitle><jtitle>Tropical biomedicine</jtitle><addtitle>Trop Biomed</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>27</volume><issue>2</issue><spage>343</spage><epage>347</epage><pages>343-347</pages><issn>0127-5720</issn><abstract>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which causes fever, rash, and arthralgia. 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| fulltext | fulltext |
| identifier | ISSN: 0127-5720 |
| ispartof | Tropical biomedicine, 2010-08, Vol.27 (2), p.343-347 |
| issn | 0127-5720 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_759876221 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Alphavirus Infections - epidemiology Chikungunya Fever Chikungunya virus - genetics Fatal Outcome Humans Male Middle Aged Phylogeny |
| title | Chikungunya virus-associated death in Malaysia |
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