Random serial sampling to evaluate efficacy of iron fortification: a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate

Random serial sampling to evaluate efficacy of iron fortification: a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate

BACKGROUND: Random serial sampling is widely used in population pharmacokinetic studies and may have advantages compared with conventional fixed time-point evaluation of iron fortification. OBJECTIVE: Our objective was to validate random serial sampling to judge the efficacy of iron fortification of...

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Veröffentlicht in:The American journal of clinical nutrition 2010-11, Vol.92 (5), p.1094-1104
Hauptverfasser: Andersson, Maria, Theis, Winfried, Zimmermann, Michael B, Foman, Jasmin Tajeri, Jäkel, Martin, Duchateau, Guus SMJE, Frenken, Leon GJ, Hurrell, Richard F
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Analysis of Variance
Anemia, Iron-Deficiency - drug therapy
Biological and medical sciences
data collection
diet study techniques
Diphosphates - therapeutic use
Double-Blind Method
Edetic Acid - therapeutic use
experimental design
Feeding. Feeding behavior
Female
Ferric Compounds - therapeutic use
Ferritins - blood
food fortification
Food, Fortified
fortified foods
Fundamental and applied biological sciences. Psychology
hemoglobin
human nutrition
Humans
Iron
Iron - metabolism
Iron - therapeutic use
Iron, Dietary - administration & dosage
Margarine
Models, Biological
nutrient reserves
Nutrition
Nutrition Assessment
nutritional intervention
nutritional status
randomized clinical trials
repletion
Sample Size
sampling
Sampling techniques
Sodium
Vertebrates: anatomy and physiology, studies on body, several organs or systems
women
Young Adult
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Zusammenfassung:BACKGROUND: Random serial sampling is widely used in population pharmacokinetic studies and may have advantages compared with conventional fixed time-point evaluation of iron fortification. OBJECTIVE: Our objective was to validate random serial sampling to judge the efficacy of iron fortification of a low-fat margarine. DESIGN: We conducted a 32-wk placebo-controlled, double-blind, iron-intervention trial in 18-40-y-old Swiss women (n = 142) with serum ferritin (SF) concentrations
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.2010.29523