Interaction of Mycoplasma arthritidis Superantigen with Human T Cells
To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not...
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| Veröffentlicht in: | Clinical infectious diseases 1993-08, Vol.17 (Supplement-1), p.S170-S175 |
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| container_end_page | S175 |
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| container_issue | Supplement-1 |
| container_start_page | S170 |
| container_title | Clinical infectious diseases |
| container_volume | 17 |
| creator | Posnett, David N. Hodtsev, Andrew S. Kabak, Shara Friedman, Steven M. Cole, Barry C. Bhardwaj, Nina |
| description | To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not all Vβ17+ TCRs are MAM-reactive. Alignment of MAM-reactive and MAM-nonreactive Vβ sequences suggests that MAM does not interact with a single site encoded by a Vβ segment but that several sites may be involved or that other TCR elements contribute to formation of the MAM recognition site. |
| doi_str_mv | 10.1093/clinids/17.Supplement_1.S170 |
| format | Article |
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Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not all Vβ17+ TCRs are MAM-reactive. Alignment of MAM-reactive and MAM-nonreactive Vβ sequences suggests that MAM does not interact with a single site encoded by a Vβ segment but that several sites may be involved or that other TCR elements contribute to formation of the MAM recognition site.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/clinids/17.Supplement_1.S170</identifier><identifier>PMID: 8399910</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Amino Acid Sequence ; Animals ; Antigens ; Antigens, Bacterial ; B lymphocytes ; Bacteriology ; Binding Sites - genetics ; Biological and medical sciences ; Cell Line ; Cell lines ; Conserved Sequence ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunologic Parameters of Mycoplasmal Infections ; Mice ; Microbiology ; Mitogens - immunology ; Molecular Sequence Data ; Molecules ; Mycoplasma - immunology ; Mycoplasma arthritidis ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Proteins ; Reactivity ; Receptors ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; Receptors, Antigen, T-Cell, alpha-beta - immunology ; Sequence Alignment ; Staphylococcus ; Superantigens ; T cell antigen receptors ; T lymphocytes ; T-Lymphocytes - immunology</subject><ispartof>Clinical infectious diseases, 1993-08, Vol.17 (Supplement-1), p.S170-S175</ispartof><rights>Copyright 1993 The University of Chicago</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-9b62917d74374b0f4092a02c816157c980ed336dc3058377b7a694a24cb5fbc03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4457229$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4457229$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,803,23929,23930,25139,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4837531$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8399910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Posnett, David N.</creatorcontrib><creatorcontrib>Hodtsev, Andrew S.</creatorcontrib><creatorcontrib>Kabak, Shara</creatorcontrib><creatorcontrib>Friedman, Steven M.</creatorcontrib><creatorcontrib>Cole, Barry C.</creatorcontrib><creatorcontrib>Bhardwaj, Nina</creatorcontrib><title>Interaction of Mycoplasma arthritidis Superantigen with Human T Cells</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not all Vβ17+ TCRs are MAM-reactive. Alignment of MAM-reactive and MAM-nonreactive Vβ sequences suggests that MAM does not interact with a single site encoded by a Vβ segment but that several sites may be involved or that other TCR elements contribute to formation of the MAM recognition site.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigens</subject><subject>Antigens, Bacterial</subject><subject>B lymphocytes</subject><subject>Bacteriology</subject><subject>Binding Sites - genetics</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Conserved Sequence</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunologic Parameters of Mycoplasmal Infections</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Mitogens - immunology</subject><subject>Molecular Sequence Data</subject><subject>Molecules</subject><subject>Mycoplasma - immunology</subject><subject>Mycoplasma arthritidis</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Proteins</subject><subject>Reactivity</subject><subject>Receptors</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><subject>Sequence Alignment</subject><subject>Staphylococcus</subject><subject>Superantigens</subject><subject>T cell antigen receptors</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtKxDAUhoMo3t9AoQtx15mkuTXgRgZ1hBHxirgJaZpqtDeTFPXtjUwZXSXwf-c_hw-AIwQnCAo81bVtbemniE_uhr6vTWPaINHkDnG4BrYRxTxlVKD1-Ic0T0mO8y2w4_0bhAjlkG6CzRwLIRDcBmeXbTBO6WC7Numq5Opbd32tfKMS5cKrs8GW1idxUaTaYF9Mm3za8JrMh0a1yX0yM3Xt98BGpWpv9sd3Fzycn93P5uni-uJydrpINYEspKJgmUC85ARzUsCKQJEpmOkcMUS5Fjk0Jcas1DjejTkvuGKCqIzoglaFhngXHC97e9d9DMYH2Viv4wWqNd3gJaexg-Q8gidLULvOe2cq2TvbKPctEZS_FuVoUSIu_1uUvxbj-OG4ZygaU66GR20xPxpz5bWqq6hGW7_ConFOMYrYwRJ786FzfzGhPMtEjNNlbH0wX6tYuXfJeGyQ86dnydjjTUaebiXBPyIXmWQ</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>Posnett, David N.</creator><creator>Hodtsev, Andrew S.</creator><creator>Kabak, Shara</creator><creator>Friedman, Steven M.</creator><creator>Cole, Barry C.</creator><creator>Bhardwaj, Nina</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930801</creationdate><title>Interaction of Mycoplasma arthritidis Superantigen with Human T Cells</title><author>Posnett, David N. ; Hodtsev, Andrew S. ; Kabak, Shara ; Friedman, Steven M. ; Cole, Barry C. ; Bhardwaj, Nina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-9b62917d74374b0f4092a02c816157c980ed336dc3058377b7a694a24cb5fbc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigens</topic><topic>Antigens, Bacterial</topic><topic>B lymphocytes</topic><topic>Bacteriology</topic><topic>Binding Sites - genetics</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Conserved Sequence</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunologic Parameters of Mycoplasmal Infections</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Mitogens - immunology</topic><topic>Molecular Sequence Data</topic><topic>Molecules</topic><topic>Mycoplasma - immunology</topic><topic>Mycoplasma arthritidis</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Proteins</topic><topic>Reactivity</topic><topic>Receptors</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - genetics</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - immunology</topic><topic>Sequence Alignment</topic><topic>Staphylococcus</topic><topic>Superantigens</topic><topic>T cell antigen receptors</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Posnett, David N.</creatorcontrib><creatorcontrib>Hodtsev, Andrew S.</creatorcontrib><creatorcontrib>Kabak, Shara</creatorcontrib><creatorcontrib>Friedman, Steven M.</creatorcontrib><creatorcontrib>Cole, Barry C.</creatorcontrib><creatorcontrib>Bhardwaj, Nina</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Posnett, David N.</au><au>Hodtsev, Andrew S.</au><au>Kabak, Shara</au><au>Friedman, Steven M.</au><au>Cole, Barry C.</au><au>Bhardwaj, Nina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of Mycoplasma arthritidis Superantigen with Human T Cells</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>17</volume><issue>Supplement-1</issue><spage>S170</spage><epage>S175</epage><pages>S170-S175</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not all Vβ17+ TCRs are MAM-reactive. Alignment of MAM-reactive and MAM-nonreactive Vβ sequences suggests that MAM does not interact with a single site encoded by a Vβ segment but that several sites may be involved or that other TCR elements contribute to formation of the MAM recognition site.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8399910</pmid><doi>10.1093/clinids/17.Supplement_1.S170</doi></addata></record> |
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| ispartof | Clinical infectious diseases, 1993-08, Vol.17 (Supplement-1), p.S170-S175 |
| issn | 1058-4838 1537-6591 |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; JSTOR Archive Collection A-Z Listing |
| subjects | Amino Acid Sequence Animals Antigens Antigens, Bacterial B lymphocytes Bacteriology Binding Sites - genetics Biological and medical sciences Cell Line Cell lines Conserved Sequence Fundamental and applied biological sciences. Psychology Humans Immunologic Parameters of Mycoplasmal Infections Mice Microbiology Mitogens - immunology Molecular Sequence Data Molecules Mycoplasma - immunology Mycoplasma arthritidis Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Proteins Reactivity Receptors Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Sequence Alignment Staphylococcus Superantigens T cell antigen receptors T lymphocytes T-Lymphocytes - immunology |
| title | Interaction of Mycoplasma arthritidis Superantigen with Human T Cells |
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