Interaction of Mycoplasma arthritidis Superantigen with Human T Cells

To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not...

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Veröffentlicht in:Clinical infectious diseases 1993-08, Vol.17 (Supplement-1), p.S170-S175
Hauptverfasser: Posnett, David N., Hodtsev, Andrew S., Kabak, Shara, Friedman, Steven M., Cole, Barry C., Bhardwaj, Nina
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Sprache:eng
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Zusammenfassung:To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not all Vβ17+ TCRs are MAM-reactive. Alignment of MAM-reactive and MAM-nonreactive Vβ sequences suggests that MAM does not interact with a single site encoded by a Vβ segment but that several sites may be involved or that other TCR elements contribute to formation of the MAM recognition site.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/17.Supplement_1.S170