Interaction of Mycoplasma arthritidis Superantigen with Human T Cells
To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not...
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Veröffentlicht in: | Clinical infectious diseases 1993-08, Vol.17 (Supplement-1), p.S170-S175 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not all Vβ17+ TCRs are MAM-reactive. Alignment of MAM-reactive and MAM-nonreactive Vβ sequences suggests that MAM does not interact with a single site encoded by a Vβ segment but that several sites may be involved or that other TCR elements contribute to formation of the MAM recognition site. |
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ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1093/clinids/17.Supplement_1.S170 |