Ventricular arrhythmia revealing mitochondrial myopathy in a 69-year-old woman

We report a case of mitochondrial myopathy (MM), assessed by histological and biochemical studies. This illness was diagnosed in a 69-year-old patient with myocardiopathy revealed by ventricular arrhythmias. The originality of this case lies in the patient's age, the mode of onset and the bioch...

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Veröffentlicht in:	European heart journal 1993-08, Vol.14 (8), p.1137-1139
Hauptverfasser:	CONSTANS, J, LEHERISSIER, A, COQUET, M, MAZAT, J. P, LETELLIER, T, DURANDET, P, ROUDAUT, R, GOSSE, P, CONRI, C, DALLOCCHIO, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Biopsy Cardiac dysrhythmias Cardiology. Vascular system Cardiomyopathies - enzymology Cardiomyopathies - pathology Endocardium - enzymology Endocardium - pathology Enzymes - metabolism Female Glutamates - metabolism Glutamic Acid Heart Humans Malates - metabolism Medical sciences Microscopy, Electron Mitochondria, Heart - enzymology Mitochondria, Heart - ultrastructure Mitochondrial Myopathies - enzymology Mitochondrial Myopathies - pathology Myocardium - enzymology Myocardium - pathology Ventricular Fibrillation - enzymology Ventricular Fibrillation - pathology
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Beschreibung
Zusammenfassung:	We report a case of mitochondrial myopathy (MM), assessed by histological and biochemical studies. This illness was diagnosed in a 69-year-old patient with myocardiopathy revealed by ventricular arrhythmias. The originality of this case lies in the patient's age, the mode of onset and the biochemical features (i.e. normal mitochondrial enzymatic complexes but very low respiration when using glutamate as a substrate).
ISSN:	0195-668X 1522-9645
DOI:	10.1093/eurheartj/14.8.1137