The isolation and structural elucidation of four novel triterpene lactones, pseudolarolides A, B, C, and D, from Pseudolarix kaempferi

Four novel triterpene lactones, pseudolarolides A [1], B [2], C [3], and D [4], were isolated from the seeds of Pseudolarix kaempferi. Their structures and stereochemistry were elucidated from spectral data. Compound 2 shows potent cytotoxicity against three human cancer cell lines, KB (nasopharynge...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1993-07, Vol.56 (7), p.1114-1122
Hauptverfasser:	Chen, G F, Li, Z L, Pan, D J, Tang, C M, He, X, Xu, G Y, Chen, K, Lee, K H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Chromatography, Thin Layer Colonic Neoplasms - drug therapy General pharmacology Humans KB Cells Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Leukemia P388 - drug therapy Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Mice Molecular Conformation Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Spectrophotometry, Ultraviolet Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Tumor Cells, Cultured
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Zusammenfassung:	Four novel triterpene lactones, pseudolarolides A [1], B [2], C [3], and D [4], were isolated from the seeds of Pseudolarix kaempferi. Their structures and stereochemistry were elucidated from spectral data. Compound 2 shows potent cytotoxicity against three human cancer cell lines, KB (nasopharyngeal), A-549 (lung), and HCT-8 (colon), and against a murine leukemia cell line (P-388) with ED50 values of 0.49, 0.67, 0.73, and 0.79 micrograms/ml, respectively.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50097a015