Physiological plasma concentrations of cholecystokinin stimulate pancreatic enzyme secretion and gallbladder contraction in man

The present study was undertaken to determine whether infusion of cholecystokinin (CCK) to plasma concentrations comparable to those found after a meal stimulates pancreatic enzyme secretion and gallbladder contraction. Plasma CCK concentrations were measured by radioimmunoassay using antibody T204,...

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Veröffentlicht in:	Life sciences (1973) 1985-02, Vol.36 (6), p.565-569
Hauptverfasser:	Kerstens, P.J.S.M., Lamers, C.B.H.W., Jansen, J.B.M.J., de Jong, A.J.L., Hessels, M., Hafkenscheid, J.C.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bilirubin - metabolism Biological and medical sciences Cholecystokinin - blood Duodenum - metabolism Female Food Fundamental and applied biological sciences. Psychology Gallbladder - physiology Gastrointestinal hormones Humans Male Muscle Contraction Pancreas - enzymology Radioimmunoassay Reference Values Trypsin - metabolism Vertebrates: digestive system
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Zusammenfassung:	The present study was undertaken to determine whether infusion of cholecystokinin (CCK) to plasma concentrations comparable to those found after a meal stimulates pancreatic enzyme secretion and gallbladder contraction. Plasma CCK concentrations were measured by radioimmunoassay using antibody T204, which binds to all carboxyl-terminal CCK-peptides containing the sulfated tyrosine region. Ingestion of a standardized test meal in 7 normal subjects induced significant increases in plasma CCK from 2.0 ± 0.2 pmol/1 to levels between 4.6 ± 0.6 and 7.3 ± 1.0 pmol/1 (p
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(85)90638-1