Antitachyphylactic Effects of Progesterone and Oxytocin on Term Human Myometrial Contractile Activity In Vitro

Antitachyphylactic Effects of Progesterone and Oxytocin on Term Human Myometrial Contractile Activity In Vitro

OBJECTIVE: METHODS: RESULTS: CONCLUSION:Progesterone stimulated the frequency of contractions and tonus of strips from the lower uterine segment of term human myometrium. A lasting increase in the frequency of contractions was observed with superfusion of progesterone plus oxytocin, suggesting that...

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Veröffentlicht in:Obstetrics and gynecology (New York. 1953) 1993-10, Vol.82 (4), p.532-538
Hauptverfasser: FU, XIN, REZAPOUR, MASOUMEH, LÖFGREN, MATS, ULMSTEN, ULF, BÄCKSTRÖM, TORBJÖRN
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Dose-Response Relationship, Drug
Female
Fundamental and applied biological sciences. Psychology
Humans
In Vitro Techniques
Mother. Fetoplacental unit. Mammary gland. Milk
Oxytocin - pharmacology
Pregnancy
Pregnancy. Parturition. Lactation
Progesterone - pharmacology
Tachyphylaxis
Uterine Contraction - drug effects
Vertebrates: reproduction
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Zusammenfassung:OBJECTIVE: METHODS: RESULTS: CONCLUSION:Progesterone stimulated the frequency of contractions and tonus of strips from the lower uterine segment of term human myometrium. A lasting increase in the frequency of contractions was observed with superfusion of progesterone plus oxytocin, suggesting that progesterone counteracted the reaction of tachyphylaxis to oxytocin. (Obstet Gynecol 1993;82:532-8)
ISSN:0029-7844
1873-233X
DOI:10.1097/00006250-199310000-00012