EFFECTS OF CARDIOPLEGIA ON MYOCARDIAL METABOLISM DURING HYPOTHERMIC ISCHEMIA : Components and mode of administration

EFFECTS OF CARDIOPLEGIA ON MYOCARDIAL METABOLISM DURING HYPOTHERMIC ISCHEMIA : Components and mode of administration

Isolated rat heart preparations were used to determine the effect of cardioplegia on myocardial metabolism during profound hypothermic (15°C) ischemia. The hearts were grouped according to the components of cardioplegia and the mode of administration. The six groups were normokalemic (GI), calcium-c...

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Veröffentlicht in:JAPANESE CIRCULATION JOURNAL 1985/01/20, Vol.49(1), pp.75-80
Hauptverfasser: KOHDA, YOSHIO, TOMINAGA, RYUJI, UENO, YASUTAKA, ANDOH, HIROMI, NAKANO, EIICHI, TOKUNAGA, KOUICHI
Format: Artikel
Sprache:eng
Schlagworte:
Adenine Nucleotides - metabolism
Adenosine Monophosphate - metabolism
Adenosine Triphosphate - metabolism
Anesthesia
Anesthesia depending on type of surgery
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Calcium - metabolism
Calcium ion
Cardioplegia
Glucose - administration & dosage
Glucosephosphates - metabolism
Heart Arrest, Induced
In Vitro Techniques
Insulin - administration & dosage
Lactates - metabolism
Lactic Acid
Male
Medical sciences
Myocardial ischemia
Myocardial metabolism
Myocardium - metabolism
Phosphocreatine - metabolism
Potassium - administration & dosage
Potassium Compounds
Rats
Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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Zusammenfassung:Isolated rat heart preparations were used to determine the effect of cardioplegia on myocardial metabolism during profound hypothermic (15°C) ischemia. The hearts were grouped according to the components of cardioplegia and the mode of administration. The six groups were normokalemic (GI), calcium-containing hyperkalemic (GII), calcium-free hyperkalemic (GIII) and single does (A), multidose (B). Following 120 min of ischemia, tissue ATP decreased from 25.4±2.2 to 10.3±2.7, 3.9±2.4, 4.1±1.2, 15.5±3.2, 14.5±2.4 and 20.0±2.7 (I-A vs II-A p
ISSN:0047-1828
1347-4839
DOI:10.1253/jcj.49.75