Contrasting Effects of Pyrazinoylguanidine and Hydrochlorothiazide in Patients with Renal Insufficiency

A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency. Pyrazinoylguanidine was saluretic, without affecting serum potassium or glucose concentrations....

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Veröffentlicht in:	Journal of clinical pharmacology 1993-06, Vol.33 (6), p.554-561
Hauptverfasser:	Beyer Jr, Karl H., Ward, Thomas D., Vary, Jean E., Gelarden, R. Thomas, Knutson, David W., Vesell, Elliot S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Blood Glucose - metabolism Cholesterol - blood Electrolytes - blood Female Guanidines - blood Guanidines - pharmacology Humans Hydrochlorothiazide - blood Hydrochlorothiazide - pharmacology Male Medical sciences Middle Aged Pharmacology. Drug treatments Pyrazines - blood Pyrazines - pharmacology Renal Insufficiency - blood Single-Blind Method Triglycerides - blood Urea - blood Urinary system
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Beschreibung
Zusammenfassung:	A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency. Pyrazinoylguanidine was saluretic, without affecting serum potassium or glucose concentrations. The onset of PZG's antihypertensive effect occurred within 4 hours. In contrast, hydrochlorothiazide (HCTZ) increased serum concentrations of urea, triglycerides, and glucose, without affecting cholesterol.
ISSN:	0091-2700 1552-4604
DOI:	10.1002/j.1552-4604.1993.tb04703.x