Neurotransmitter-induced modulation of neuronal Ca current is not mediated by intracellular Ca2+ or cAMP

Neurotransmitter-induced modulation of neuronal Ca current is not mediated by intracellular Ca2+ or cAMP

Dopamine (1 microM) inhibits the Ca component of action potential and corresponding electroexcitable Ca current (ICa) in isolated snail neurons. Adrenaline and serotonin also reduce ICa. The inhibition is not related to changes in intracellular Ca2+ or cAMP concentrations: internal application of 10...

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Veröffentlicht in:Brain research 1985-02, Vol.326 (1), p.145-148
Hauptverfasser: Akopyan, A R, Chemeris, N K, Iljin, V I
Format: Artikel
Sprache:eng
Schlagworte:
Action Potentials - drug effects
Animals
Calcium - physiology
Cyclic AMP - physiology
Epinephrine - pharmacology
Ganglia - physiology
Lymnaea
Neurotransmitter Agents - pharmacology
Serotonin - pharmacology
Synaptic Transmission - drug effects
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Zusammenfassung:Dopamine (1 microM) inhibits the Ca component of action potential and corresponding electroexcitable Ca current (ICa) in isolated snail neurons. Adrenaline and serotonin also reduce ICa. The inhibition is not related to changes in intracellular Ca2+ or cAMP concentrations: internal application of 10 mM ethyleneglycoltetraacetic acid or 10 microM cAMP in the mixture with 1 mM Mg-ATP and 2 mM theophylline does not influence the action of neurotransmitters on ICa.
ISSN:0006-8993
DOI:10.1016/0006-8993(85)91393-9