Reduced high affinity cholecystokinin binding in hippocampus and frontal cortex of schizophrenic patients

Cholecystokinin (CCK) binding sites were assessed in post-mortem brain membrane preparations from controls and schizophrenic patients. 125I-BH CCK 33 specific binding was reduced by 40% (p

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Bibliographische Detailangaben
Veröffentlicht in:	Life Sci.; (United States) 1985-02, Vol.36 (5), p.473-477
Hauptverfasser:	Farmery, S.M., Owen, F., Poulter, M., Crow, T.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques Adult AFFINITY Aged Amygdala - metabolism AUTOPSY BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES Binding Sites Biological and medical sciences BODY BRAIN Caudate Nucleus - metabolism CELL CONSTITUENTS CELL MEMBRANES CENTRAL NERVOUS SYSTEM Cerebral Cortex - metabolism CHEMICAL BONDS cholecystokinin Cholecystokinin - metabolism DAYS LIVING RADIOISOTOPES DIAGNOSTIC TECHNIQUES ELECTRON CAPTURE RADIOISOTOPES Female Hippocampus - metabolism Humans INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES ISOTOPE APPLICATIONS ISOTOPES LABELLED COMPOUNDS Male man Medical sciences MEMBRANES MENTAL DISORDERS Middle Aged Miscellaneous NERVOUS SYSTEM NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANS PATIENTS PEPTIDES POLYPEPTIDES PROTEINS Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry RADIOISOTOPES schizophrenia Schizophrenia - metabolism Techniques and methods TRACER TECHNIQUES
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Beschreibung
Zusammenfassung:	Cholecystokinin (CCK) binding sites were assessed in post-mortem brain membrane preparations from controls and schizophrenic patients. 125I-BH CCK 33 specific binding was reduced by 40% (p
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(85)90260-7