Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids
This chapter reviews information on organs in various species that are involved in the synthesis and degradation of low density lipoprotein cholesterol (LDL-C). The quantitative relationships between these processes are also described and the manner in which dietary cholesterol and triglycerides alt...
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| Veröffentlicht in: | Annual review of nutrition 1993, Vol.13 (1), p.355-381 |
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| container_title | Annual review of nutrition |
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| creator | Spady, D.K Wollett, L.A Dietschy, J.M |
| description | This chapter reviews information on organs in various species that are involved in the synthesis and degradation of low density lipoprotein cholesterol (LDL-C). The quantitative relationships between these processes are also described and the manner in which dietary cholesterol and triglycerides alter these processes is reviewed. A model is presented that suggests how fatty acids and cholesterol interact biochemically to bring about the marked changes in the steady-state concentration of LDL-C observed in both experimental animals and humans |
| doi_str_mv | 10.1146/annurev.nu.13.070193.002035 |
| format | Article |
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The quantitative relationships between these processes are also described and the manner in which dietary cholesterol and triglycerides alter these processes is reviewed. A model is presented that suggests how fatty acids and cholesterol interact biochemically to bring about the marked changes in the steady-state concentration of LDL-C observed in both experimental animals and humans</description><identifier>ISSN: 0199-9885</identifier><identifier>EISSN: 1545-4312</identifier><identifier>DOI: 10.1146/annurev.nu.13.070193.002035</identifier><identifier>PMID: 8369151</identifier><identifier>CODEN: ARNTD8</identifier><language>eng</language><publisher>Palo Alto, CA: Annual Reviews</publisher><subject>ACIDE GRAS ; ACIDOS GRASOS ; Animals ; Biological and medical sciences ; BIOSINTESIS ; BIOSYNTHESE ; CHIMIORECEPTEUR ; CHOLESTEROL ; Cholesterol, Dietary - administration & dosage ; Cholesterol, Dietary - metabolism ; Cholesterol, LDL - blood ; Cholesterol, LDL - metabolism ; CIRCULACION SANGUINEA ; CIRCULATION SANGUINE ; COLESTEROL ; CORPS GRAS ; DIETA ; Dietary Fats - administration & dosage ; Fatty Acids - administration & dosage ; Feeding. 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Psychology ; GRASAS ; Humans ; LIPOPROTEINAS ; LIPOPROTEINE ; METABOLISME DES LIPIDES ; METABOLISMO DE LIPIDOS ; MODELE ; MODELOS ; NUTRIENTES ; QUIMIORECEPTORS ; Receptors, LDL - drug effects ; Receptors, LDL - metabolism ; REGIME ALIMENTAIRE ; SUBSTANCE NUTRITIVE ; TRIGLICERIDOS ; TRIGLYCERIDE ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Annual review of nutrition, 1993, Vol.13 (1), p.355-381</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c308t-6fd672cdc65f7fe436c8dd1e6ce27b2ce50a24da85eb205ec1be17838b2ddd5e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,4167,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3759507$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8369151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spady, D.K</creatorcontrib><creatorcontrib>Wollett, L.A</creatorcontrib><creatorcontrib>Dietschy, J.M</creatorcontrib><title>Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids</title><title>Annual review of nutrition</title><addtitle>Annu Rev Nutr</addtitle><description>This chapter reviews information on organs in various species that are involved in the synthesis and degradation of low density lipoprotein cholesterol (LDL-C). The quantitative relationships between these processes are also described and the manner in which dietary cholesterol and triglycerides alter these processes is reviewed. A model is presented that suggests how fatty acids and cholesterol interact biochemically to bring about the marked changes in the steady-state concentration of LDL-C observed in both experimental animals and humans</description><subject>ACIDE GRAS</subject><subject>ACIDOS GRASOS</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BIOSINTESIS</subject><subject>BIOSYNTHESE</subject><subject>CHIMIORECEPTEUR</subject><subject>CHOLESTEROL</subject><subject>Cholesterol, Dietary - administration & dosage</subject><subject>Cholesterol, Dietary - metabolism</subject><subject>Cholesterol, LDL - blood</subject><subject>Cholesterol, LDL - metabolism</subject><subject>CIRCULACION SANGUINEA</subject><subject>CIRCULATION SANGUINE</subject><subject>COLESTEROL</subject><subject>CORPS GRAS</subject><subject>DIETA</subject><subject>Dietary Fats - administration & dosage</subject><subject>Fatty Acids - administration & dosage</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GRASAS</subject><subject>Humans</subject><subject>LIPOPROTEINAS</subject><subject>LIPOPROTEINE</subject><subject>METABOLISME DES LIPIDES</subject><subject>METABOLISMO DE LIPIDOS</subject><subject>MODELE</subject><subject>MODELOS</subject><subject>NUTRIENTES</subject><subject>QUIMIORECEPTORS</subject><subject>Receptors, LDL - drug effects</subject><subject>Receptors, LDL - metabolism</subject><subject>REGIME ALIMENTAIRE</subject><subject>SUBSTANCE NUTRITIVE</subject><subject>TRIGLICERIDOS</subject><subject>TRIGLYCERIDE</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0199-9885</issn><issn>1545-4312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtr3DAURkVoSCdp_kChIGjIzhM9LFsmq5CkbWAgMG3W4lq6Sl009kSyB-bfV8UmdHUX37mvQ8hXztacl9UN9P0U8bDupzWXa1Yz3uTCBJPqhKy4KlVRSi4-kFVOmqLRWn0k5yn9YYw1UsozcqZl1XDFV2S7xdcpwNgNPR083QdIO6Cbh01hfw8B04hxCDTgAUOi7ZG6DkeIR_p_Cr2jHsbxSMF2Ln0ipx5CwsulXpCXb4-_7n8Um-fvT_d3ebJkeiwq76paWGcr5WuPpaysdo5jZVHUrbCoGIjSgVbYCqbQ8hZ5raVuhXNOobwg1_PcfRzepnyM2XXJYgjQ4zAlU6umVJzxDN7OoI1DShG92cdul78wnJl_Rs1i1PST4dLMRs1sNHd_WdZM7Q7de--iMOdXSw7JQvARetuld0zmMxSrM_Z5xjwMBl5jRl5-NqVQUjfyL7mPi_E</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Spady, D.K</creator><creator>Wollett, L.A</creator><creator>Dietschy, J.M</creator><general>Annual Reviews</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids</title><author>Spady, D.K ; Wollett, L.A ; Dietschy, J.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c308t-6fd672cdc65f7fe436c8dd1e6ce27b2ce50a24da85eb205ec1be17838b2ddd5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>ACIDE GRAS</topic><topic>ACIDOS GRASOS</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BIOSINTESIS</topic><topic>BIOSYNTHESE</topic><topic>CHIMIORECEPTEUR</topic><topic>CHOLESTEROL</topic><topic>Cholesterol, Dietary - administration & dosage</topic><topic>Cholesterol, Dietary - metabolism</topic><topic>Cholesterol, LDL - blood</topic><topic>Cholesterol, LDL - metabolism</topic><topic>CIRCULACION SANGUINEA</topic><topic>CIRCULATION SANGUINE</topic><topic>COLESTEROL</topic><topic>CORPS GRAS</topic><topic>DIETA</topic><topic>Dietary Fats - administration & dosage</topic><topic>Fatty Acids - administration & dosage</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GRASAS</topic><topic>Humans</topic><topic>LIPOPROTEINAS</topic><topic>LIPOPROTEINE</topic><topic>METABOLISME DES LIPIDES</topic><topic>METABOLISMO DE LIPIDOS</topic><topic>MODELE</topic><topic>MODELOS</topic><topic>NUTRIENTES</topic><topic>QUIMIORECEPTORS</topic><topic>Receptors, LDL - drug effects</topic><topic>Receptors, LDL - metabolism</topic><topic>REGIME ALIMENTAIRE</topic><topic>SUBSTANCE NUTRITIVE</topic><topic>TRIGLICERIDOS</topic><topic>TRIGLYCERIDE</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spady, D.K</creatorcontrib><creatorcontrib>Wollett, L.A</creatorcontrib><creatorcontrib>Dietschy, J.M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spady, D.K</au><au>Wollett, L.A</au><au>Dietschy, J.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids</atitle><jtitle>Annual review of nutrition</jtitle><addtitle>Annu Rev Nutr</addtitle><date>1993</date><risdate>1993</risdate><volume>13</volume><issue>1</issue><spage>355</spage><epage>381</epage><pages>355-381</pages><issn>0199-9885</issn><eissn>1545-4312</eissn><coden>ARNTD8</coden><abstract>This chapter reviews information on organs in various species that are involved in the synthesis and degradation of low density lipoprotein cholesterol (LDL-C). The quantitative relationships between these processes are also described and the manner in which dietary cholesterol and triglycerides alter these processes is reviewed. A model is presented that suggests how fatty acids and cholesterol interact biochemically to bring about the marked changes in the steady-state concentration of LDL-C observed in both experimental animals and humans</abstract><cop>Palo Alto, CA</cop><pub>Annual Reviews</pub><pmid>8369151</pmid><doi>10.1146/annurev.nu.13.070193.002035</doi><tpages>27</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0199-9885 |
| ispartof | Annual review of nutrition, 1993, Vol.13 (1), p.355-381 |
| issn | 0199-9885 1545-4312 |
| language | eng |
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| source | Annual Reviews; MEDLINE |
| subjects | ACIDE GRAS ACIDOS GRASOS Animals Biological and medical sciences BIOSINTESIS BIOSYNTHESE CHIMIORECEPTEUR CHOLESTEROL Cholesterol, Dietary - administration & dosage Cholesterol, Dietary - metabolism Cholesterol, LDL - blood Cholesterol, LDL - metabolism CIRCULACION SANGUINEA CIRCULATION SANGUINE COLESTEROL CORPS GRAS DIETA Dietary Fats - administration & dosage Fatty Acids - administration & dosage Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology GRASAS Humans LIPOPROTEINAS LIPOPROTEINE METABOLISME DES LIPIDES METABOLISMO DE LIPIDOS MODELE MODELOS NUTRIENTES QUIMIORECEPTORS Receptors, LDL - drug effects Receptors, LDL - metabolism REGIME ALIMENTAIRE SUBSTANCE NUTRITIVE TRIGLICERIDOS TRIGLYCERIDE Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids |
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