Effects of dexamethasone on the hepatic cytochrome P450IIIA subfamily in two hamster strains Mesocricetus auratus and Cricetus griseus

1. Administration of dexamethasone significantly reduced the amount of hepatic cytochrome P450 in Syrian golden and Chinese hamsters, while it increased the amount in rats. 2. In contrast to rats, the induction rate of the activities of erythromycin and troleandomycin N-demethylases by dexamethasone...

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Veröffentlicht in:	Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Comparative pharmacology and toxicology, 1993-03, Vol.104 (3), p.433-437
Hauptverfasser:	ANTIGNAC, E, FUKUHARA, M, KIMURA, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Blotting, Western Cricetinae Cricetulus Cytochrome P-450 Enzyme System - metabolism Dexamethasone - pharmacology Electrophoresis, Polyacrylamide Gel Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Liver - drug effects Liver - enzymology Male Mesocricetus Oxidoreductases Rats Rats, Sprague-Dawley Species Specificity Spectrophotometry, Ultraviolet
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Zusammenfassung:	1. Administration of dexamethasone significantly reduced the amount of hepatic cytochrome P450 in Syrian golden and Chinese hamsters, while it increased the amount in rats. 2. In contrast to rats, the induction rate of the activities of erythromycin and troleandomycin N-demethylases by dexamethasone was relatively low, while that of the testosterone 6 beta-hydroxylase was high in the two hamster strains. 3. Western blot analysis revealed that dexamethasone did not modify markedly the pattern of the P450IIIA subfamily proteins in the two hamster strains.
ISSN:	0742-8413