Abrogation of macrophage-mediated suppression of T-lymphocyte proliferation with hemoglobin and hemin is a function of iron content

Hemoglobin, hemin, and ferric ion (Fe) were shown to reverse peritoneal exudate cell (PEC)-mediated suppression of concanavalin A-elicited murine spleen cell activation. Titration of hemoglobin and hemin relative to Fe showed a direct relationship between Fe content and reversal of PEC suppression....

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Veröffentlicht in:Cellular immunology 1985, Vol.90 (1), p.267-273
1. Verfasser: Walker, Sharyn M.
Format: Artikel
Sprache:eng
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Zusammenfassung:Hemoglobin, hemin, and ferric ion (Fe) were shown to reverse peritoneal exudate cell (PEC)-mediated suppression of concanavalin A-elicited murine spleen cell activation. Titration of hemoglobin and hemin relative to Fe showed a direct relationship between Fe content and reversal of PEC suppression. Indomethacin enhanced the capacity of all three compounds to abrogate PEC suppression on the order of five- to eight-fold. The capacity of endogenous Fecontaining substances as hemoglobin and its catabolites, e.g., hemin, to modulate macrophage expression may be of special significance at sites of inflammation.
ISSN:0008-8749
1090-2163
DOI:10.1016/0008-8749(85)90189-3