A macromolecular shape function based on sedimentation velocity parameters

A volume-independent shape function, experimentally determinable from sedimentation velocity experiments, was formulated explicitly in terms of the axial ratio of a macromolecule considered as an ellipsoid of revolution. Use of this function offers a simple first approach to the elucidation of macro...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1985, Vol.236 (1), p.338-341
Hauptverfasser:	Nichol, Lawrence W., Owen, Elisabeth A., Winzor, Donald J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Centrifugation Fundamental and applied biological sciences. Psychology Kinetics Macromolecular Substances Mathematics Models, Chemical Molecular biophysics Molecular Weight Myosins Ovalbumin Physico-chemical properties of biomolecules Proteins Serum Albumin, Bovine Water
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Beschreibung
Zusammenfassung:	A volume-independent shape function, experimentally determinable from sedimentation velocity experiments, was formulated explicitly in terms of the axial ratio of a macromolecule considered as an ellipsoid of revolution. Use of this function offers a simple first approach to the elucidation of macromolecular geometry as illustrated by calculations for ovalbumin, bovine serum albumin, and myosin.
ISSN:	0003-9861 1096-0384
DOI:	10.1016/0003-9861(85)90634-4