SYNTHESIS OF NEW ANTINEOPLASTIC PROSTAGLANDINS
The three-component coupling process allows a single-pot entry to protected 7-hydroxy-PGE1 derivatives, leading to a variety of new PGs functionalized or unsaturated at C-7. The enone and dienone derivatives exhibit potent inhibitory activity on L1210 tumor cell growth in vitro.
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1984/11/25, Vol.32(11), pp.4658-4661 |
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| container_end_page | 4661 |
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| container_issue | 11 |
| container_start_page | 4658 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 32 |
| creator | Sugiura, Satoshi Toru, Takeshi Tanaka, Toshio Hazato, Atsuo Okamura, Noriaki Bannai, Kiyoshi Manabe, Kenji Kurozumi, Seizi Noyori, Ryoji |
| description | The three-component coupling process allows a single-pot entry to protected 7-hydroxy-PGE1 derivatives, leading to a variety of new PGs functionalized or unsaturated at C-7. The enone and dienone derivatives exhibit potent inhibitory activity on L1210 tumor cell growth in vitro. |
| doi_str_mv | 10.1248/cpb.32.4658 |
| format | Article |
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Pharm. Bull.</addtitle><description>The three-component coupling process allows a single-pot entry to protected 7-hydroxy-PGE1 derivatives, leading to a variety of new PGs functionalized or unsaturated at C-7. 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| fulltext | fulltext |
| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1984/11/25, Vol.32(11), pp.4658-4661 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75934953 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Alicyclic compounds, terpenoids, prostaglandins, steroids Animals antineoplastic Antineoplastic Agents - chemical synthesis Chemical Phenomena Chemistry Exact sciences and technology Leukemia L1210 - drug therapy Mice Organic chemistry Preparations and properties Prostaglandins Prostaglandins - chemical synthesis Prostaglandins - pharmacology |
| title | SYNTHESIS OF NEW ANTINEOPLASTIC PROSTAGLANDINS |
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