SYNTHESIS OF NEW ANTINEOPLASTIC PROSTAGLANDINS

The three-component coupling process allows a single-pot entry to protected 7-hydroxy-PGE1 derivatives, leading to a variety of new PGs functionalized or unsaturated at C-7. The enone and dienone derivatives exhibit potent inhibitory activity on L1210 tumor cell growth in vitro.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1984/11/25, Vol.32(11), pp.4658-4661
Hauptverfasser:	Sugiura, Satoshi, Toru, Takeshi, Tanaka, Toshio, Hazato, Atsuo, Okamura, Noriaki, Bannai, Kiyoshi, Manabe, Kenji, Kurozumi, Seizi, Noyori, Ryoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Animals antineoplastic Antineoplastic Agents - chemical synthesis Chemical Phenomena Chemistry Exact sciences and technology Leukemia L1210 - drug therapy Mice Organic chemistry Preparations and properties Prostaglandins Prostaglandins - chemical synthesis Prostaglandins - pharmacology
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Beschreibung
Zusammenfassung:	The three-component coupling process allows a single-pot entry to protected 7-hydroxy-PGE1 derivatives, leading to a variety of new PGs functionalized or unsaturated at C-7. The enone and dienone derivatives exhibit potent inhibitory activity on L1210 tumor cell growth in vitro.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.32.4658