Relationships between proteasomes and viral gene products

The interrelationships between proteasomes and viral gene products are very complex. 20S proteasomes associate with a number of viral mRNAs which are cleaved by proteasome's associated endonuclease activity. In addition proteasome's endopeptidase activities are involved in the presentation...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular biology reports 1999-04, Vol.26 (1-2), p.113-117
Hauptverfasser:	Jarrousse, A S, Gautier, K, Apcher, S, Badaoui, S, Boissonnet, G, Dadet, M H, Henry, L, Bureau, J P, Schmid, H P, Petit, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism AIDS/HIV Antigen presentation Cysteine Endopeptidases - metabolism Endonuclease endopeptidase Enzymatic activity Enzymes HIV HIV - metabolism HIV Long Terminal Repeat Human immunodeficiency virus Humans mRNA Multienzyme Complexes - metabolism Proteasome Endopeptidase Complex proteasomes RNA, Messenger - metabolism RNA, Transfer, Amino Acyl - metabolism RNA, Viral - metabolism Viral Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The interrelationships between proteasomes and viral gene products are very complex. 20S proteasomes associate with a number of viral mRNAs which are cleaved by proteasome's associated endonuclease activity. In addition proteasome's endopeptidase activities are involved in the presentation of viral antigens. Viral proteins of different origin associate with the 20S and 26S complexes and interfere with their enzymatic activities. A major part of this review deals with the interactions between 20S proteasomes and the gene products of the human immunodeficiency virus (HIV) which has been studied in detail by our group.
ISSN:	0301-4851 1573-4978
DOI:	10.1023/A:1006982023524