The Role of Hemoglobin Denaturation and Band 3 Clustering in Red Blood Cell Aging

As hemoglobin begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane--spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its remo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1985-02, Vol.227 (4686), p.531-533
Hauptverfasser:	Low, Philip S., Waugh, Stephen M., Zinke, Karen, Drenckhahn, Detlev
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines Ageing, cell death Anion Exchange Protein 1, Erythrocyte - immunology Anion Exchange Protein 1, Erythrocyte - metabolism Antibodies Biological and medical sciences Blood proteins Cell aggregates Cell physiology Cellular senescence Demonstrations and protests Epitopes Erythrocyte Aging Erythrocytes Erythrocytes - immunology Fundamental and applied biological sciences. Psychology Heinz bodies Hematocrit Hemoglobin Hemoglobins Hemoglobins - metabolism Humans Immunoglobulin G - immunology Macromolecular Substances Molecular and cellular biology Phenylhydrazines Phenylhydrazines - pharmacology Physiological aspects Protein Denaturation Proteins Red blood cells Room temperature
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