The Role of Hemoglobin Denaturation and Band 3 Clustering in Red Blood Cell Aging

As hemoglobin begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane--spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its remo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1985-02, Vol.227 (4686), p.531-533
Hauptverfasser:	Low, Philip S., Waugh, Stephen M., Zinke, Karen, Drenckhahn, Detlev
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines Ageing, cell death Anion Exchange Protein 1, Erythrocyte - immunology Anion Exchange Protein 1, Erythrocyte - metabolism Antibodies Biological and medical sciences Blood proteins Cell aggregates Cell physiology Cellular senescence Demonstrations and protests Epitopes Erythrocyte Aging Erythrocytes Erythrocytes - immunology Fundamental and applied biological sciences. Psychology Heinz bodies Hematocrit Hemoglobin Hemoglobins Hemoglobins - metabolism Humans Immunoglobulin G - immunology Macromolecular Substances Molecular and cellular biology Phenylhydrazines Phenylhydrazines - pharmacology Physiological aspects Protein Denaturation Proteins Red blood cells Room temperature
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Beschreibung
Zusammenfassung:	As hemoglobin begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane--spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its removal from circulation.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.2578228