Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1993-08, Vol.36 (16), p.2420-2423
Hauptverfasser:	Flynn, Gary A, Beight, Douglas W, Mehdi, Shujaath, Koehl, Jack R, Giroux, Eugene L, French, John F, Hake, Paul W, Dage, Richard C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Angiotensin-Converting Enzyme Inhibitors - chemistry Animals Biological and medical sciences Blood Pressure - drug effects Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Neprilysin - antagonists & inhibitors Neprilysin - chemistry Oligopeptides - chemical synthesis Oligopeptides - pharmacology Protein Conformation Rats Rats, Inbred SHR Structure-Activity Relationship Sympathomimetics - analogs & derivatives Sympathomimetics - chemical synthesis Sympathomimetics - pharmacology
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