Changes in water diffusion and relaxation properties of rat cerebrum during status epilepticus

Diffusion‐weighted (DW) imaging has been used to record changes associated with status epilepticus (SE) in rat brain. It was found that the apparent diffusion coefficient (ADC) of water in brain decreased14–18% during SE, and it fell a further 20–22% when the animals were sacrificed. The transverse...

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Veröffentlicht in:	Magnetic resonance in medicine 1993-08, Vol.30 (2), p.241-246
Hauptverfasser:	Zhong, J., Petroff, O. A. C., Prichard, J. W., Gore, J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences brain Brain - pathology Diffusion Female Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Medical sciences MRI Nervous system Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rats status epilepticus Status Epilepticus - diagnosis Water - metabolism water diffusion coefficient
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Zusammenfassung:	Diffusion‐weighted (DW) imaging has been used to record changes associated with status epilepticus (SE) in rat brain. It was found that the apparent diffusion coefficient (ADC) of water in brain decreased14–18% during SE, and it fell a further 20–22% when the animals were sacrificed. The transverse decay time constant T2 showed corresponding reductions, but no significant changes were seen in relaxation times T1 or T2 values. Changes in ADC in status epilepticus are similar to those seen in stroke and ischemia but occur under very differ ret conditions of blood flow and metabolism.
ISSN:	0740-3194 1522-2594
DOI:	10.1002/mrm.1910300214