Studies of the vasorelaxant effect of acetate

Studies of the vasorelaxant effect of acetate

Sodium acetate caused dose-dependent relaxation of helical rat tail artery strips constricted by phenylephrine, potassium chloride and arginine vasopressin. Substantial relaxation was evident at acetate concentrations as low as 4 mM. The results suggest that the vasodilatation of acetate is not limi...

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Veröffentlicht in:Transactions - American Society for Artificial Internal Organs 1984, Vol.30, p.65-68
Hauptverfasser: Daugirdas, J T, Nawab, Z M, Ing, T S, Leehey, D J, Yang, M C, Pang, P K, Klok, M A
Format: Artikel
Sprache:eng
Schlagworte:
Acetates - pharmacology
Acetic Acid
Animals
Dose-Response Relationship, Drug
Male
Muscle, Smooth, Vascular - drug effects
Rats
Rats, Inbred Strains
Vasoconstrictor Agents - pharmacology
Vasodilation - drug effects
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Zusammenfassung:Sodium acetate caused dose-dependent relaxation of helical rat tail artery strips constricted by phenylephrine, potassium chloride and arginine vasopressin. Substantial relaxation was evident at acetate concentrations as low as 4 mM. The results suggest that the vasodilatation of acetate is not limited to receptor-dependent or voltage-dependent mechanisms. Acute increases in bath sodium chloride concentration resulted in marked relaxation of vessel strips constricted by phenylephrine and potassium chloride. Arginine vasopressin-constricted strips were quite resistant to the vasorelaxant effect of increased bath sodium chloride.
ISSN:0066-0078