A pilot study using 99mTc to measure lead and platinum in the human kidney
A pilot study has been conducted to investigate the hypothesis that the chemotherapeutic drug, cisplatinum, can mobilize skeletal lead. In vivo measurements of lead and platinum in the kidney of chemotherapy patients were performed with the technique of x-ray fluorescence, using 99mTc in a backscatt...
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| Veröffentlicht in: | Nuclear medicine and biology 1993-07, Vol.20 (5), p.589-595 |
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| container_issue | 5 |
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| container_title | Nuclear medicine and biology |
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| creator | Todd, A.C. Chettle, D.R. Scott, M.C. Somervaille, L.J. Braithwaite, R.A. Beaney, R.P. Buxton, E.J. |
| description | A pilot study has been conducted to investigate the hypothesis that the chemotherapeutic drug, cisplatinum, can mobilize skeletal lead.
In vivo measurements of lead and platinum in the kidney of chemotherapy patients were performed with the technique of x-ray fluorescence, using
99mTc in a backscatter geometry. The results of the pilot study were inconclusive; the majority of patients exhibited no evidence of kidney lead at the level of system sensitivity, and negligible blood and urine lead levels. |
| doi_str_mv | 10.1016/0969-8051(93)90027-R |
| format | Article |
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In vivo measurements of lead and platinum in the kidney of chemotherapy patients were performed with the technique of x-ray fluorescence, using
99mTc in a backscatter geometry. The results of the pilot study were inconclusive; the majority of patients exhibited no evidence of kidney lead at the level of system sensitivity, and negligible blood and urine lead levels.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/0969-8051(93)90027-R</identifier><identifier>PMID: 8358344</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cisplatin - metabolism ; Cisplatin - therapeutic use ; Female ; Humans ; Kidney - chemistry ; Kidney - diagnostic imaging ; Lead - analysis ; Lead - blood ; Lead - urine ; Male ; Neoplasms - drug therapy ; Pilot Projects ; Platinum - analysis ; Radionuclide Imaging ; Spectrometry, X-Ray Emission ; Technetium</subject><ispartof>Nuclear medicine and biology, 1993-07, Vol.20 (5), p.589-595</ispartof><rights>1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2044-203aba59d9e3cb73fed4ae6e26a36e9ca7060d8c1e079eaa616d9c814202c8753</citedby><cites>FETCH-LOGICAL-c2044-203aba59d9e3cb73fed4ae6e26a36e9ca7060d8c1e079eaa616d9c814202c8753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/096980519390027R$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8358344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Todd, A.C.</creatorcontrib><creatorcontrib>Chettle, D.R.</creatorcontrib><creatorcontrib>Scott, M.C.</creatorcontrib><creatorcontrib>Somervaille, L.J.</creatorcontrib><creatorcontrib>Braithwaite, R.A.</creatorcontrib><creatorcontrib>Beaney, R.P.</creatorcontrib><creatorcontrib>Buxton, E.J.</creatorcontrib><title>A pilot study using 99mTc to measure lead and platinum in the human kidney</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>A pilot study has been conducted to investigate the hypothesis that the chemotherapeutic drug, cisplatinum, can mobilize skeletal lead.
In vivo measurements of lead and platinum in the kidney of chemotherapy patients were performed with the technique of x-ray fluorescence, using
99mTc in a backscatter geometry. The results of the pilot study were inconclusive; the majority of patients exhibited no evidence of kidney lead at the level of system sensitivity, and negligible blood and urine lead levels.</description><subject>Cisplatin - metabolism</subject><subject>Cisplatin - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney - chemistry</subject><subject>Kidney - diagnostic imaging</subject><subject>Lead - analysis</subject><subject>Lead - blood</subject><subject>Lead - urine</subject><subject>Male</subject><subject>Neoplasms - drug therapy</subject><subject>Pilot Projects</subject><subject>Platinum - analysis</subject><subject>Radionuclide Imaging</subject><subject>Spectrometry, X-Ray Emission</subject><subject>Technetium</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LwzAYx4Moc06_gUJOoodq0qRpcxHG8JWBMOY5ZMkzjbbpTBph397OjR09PYf_G88PoXNKbiih4pZIIbOKFPRKsmtJSF5mswM0pFWZZ1JQfoiGe8sxOonxk_QxTskADSpWVIzzIXoZ45Wr2w7HLtk1TtH5dyxlMze4a3EDOqYAuAZtsfYWr2rdOZ8a7DzuPgB_pEZ7_OWsh_UpOlrqOsLZ7o7Q28P9fPKUTV8fnyfjaWZywnmWE6YXupBWAjOLki3Bcg0CcqGZAGl0SQSxlaFASglaCyqsNBXlOclNVRZshC63vavQfieInWpcNFDX2kOboioLmTPGWW_kW6MJbYwBlmoVXKPDWlGiNgjVho_a8FGSqT-EatbHLnb9adGA3Yd2zHr9bqtD_-SPg6CiceANWBfAdMq27v-BX6ZBf2E</recordid><startdate>199307</startdate><enddate>199307</enddate><creator>Todd, A.C.</creator><creator>Chettle, D.R.</creator><creator>Scott, M.C.</creator><creator>Somervaille, L.J.</creator><creator>Braithwaite, R.A.</creator><creator>Beaney, R.P.</creator><creator>Buxton, E.J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199307</creationdate><title>A pilot study using 99mTc to measure lead and platinum in the human kidney</title><author>Todd, A.C. ; Chettle, D.R. ; Scott, M.C. ; Somervaille, L.J. ; Braithwaite, R.A. ; Beaney, R.P. ; Buxton, E.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2044-203aba59d9e3cb73fed4ae6e26a36e9ca7060d8c1e079eaa616d9c814202c8753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Cisplatin - metabolism</topic><topic>Cisplatin - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney - chemistry</topic><topic>Kidney - diagnostic imaging</topic><topic>Lead - analysis</topic><topic>Lead - blood</topic><topic>Lead - urine</topic><topic>Male</topic><topic>Neoplasms - drug therapy</topic><topic>Pilot Projects</topic><topic>Platinum - analysis</topic><topic>Radionuclide Imaging</topic><topic>Spectrometry, X-Ray Emission</topic><topic>Technetium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Todd, A.C.</creatorcontrib><creatorcontrib>Chettle, D.R.</creatorcontrib><creatorcontrib>Scott, M.C.</creatorcontrib><creatorcontrib>Somervaille, L.J.</creatorcontrib><creatorcontrib>Braithwaite, R.A.</creatorcontrib><creatorcontrib>Beaney, R.P.</creatorcontrib><creatorcontrib>Buxton, E.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Todd, A.C.</au><au>Chettle, D.R.</au><au>Scott, M.C.</au><au>Somervaille, L.J.</au><au>Braithwaite, R.A.</au><au>Beaney, R.P.</au><au>Buxton, E.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pilot study using 99mTc to measure lead and platinum in the human kidney</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>1993-07</date><risdate>1993</risdate><volume>20</volume><issue>5</issue><spage>589</spage><epage>595</epage><pages>589-595</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>A pilot study has been conducted to investigate the hypothesis that the chemotherapeutic drug, cisplatinum, can mobilize skeletal lead.
In vivo measurements of lead and platinum in the kidney of chemotherapy patients were performed with the technique of x-ray fluorescence, using
99mTc in a backscatter geometry. The results of the pilot study were inconclusive; the majority of patients exhibited no evidence of kidney lead at the level of system sensitivity, and negligible blood and urine lead levels.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8358344</pmid><doi>10.1016/0969-8051(93)90027-R</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0969-8051 |
| ispartof | Nuclear medicine and biology, 1993-07, Vol.20 (5), p.589-595 |
| issn | 0969-8051 1872-9614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75923343 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Cisplatin - metabolism Cisplatin - therapeutic use Female Humans Kidney - chemistry Kidney - diagnostic imaging Lead - analysis Lead - blood Lead - urine Male Neoplasms - drug therapy Pilot Projects Platinum - analysis Radionuclide Imaging Spectrometry, X-Ray Emission Technetium |
| title | A pilot study using 99mTc to measure lead and platinum in the human kidney |
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