A pilot study using 99mTc to measure lead and platinum in the human kidney

A pilot study using 99mTc to measure lead and platinum in the human kidney

A pilot study has been conducted to investigate the hypothesis that the chemotherapeutic drug, cisplatinum, can mobilize skeletal lead. In vivo measurements of lead and platinum in the kidney of chemotherapy patients were performed with the technique of x-ray fluorescence, using 99mTc in a backscatt...

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Veröffentlicht in:Nuclear medicine and biology 1993-07, Vol.20 (5), p.589-595
Hauptverfasser: Todd, A.C., Chettle, D.R., Scott, M.C., Somervaille, L.J., Braithwaite, R.A., Beaney, R.P., Buxton, E.J.
Format: Artikel
Sprache:eng
Schlagworte:
Cisplatin - metabolism
Cisplatin - therapeutic use
Female
Humans
Kidney - chemistry
Kidney - diagnostic imaging
Lead - analysis
Lead - blood
Lead - urine
Male
Neoplasms - drug therapy
Pilot Projects
Platinum - analysis
Radionuclide Imaging
Spectrometry, X-Ray Emission
Technetium
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Beschreibung
Zusammenfassung:A pilot study has been conducted to investigate the hypothesis that the chemotherapeutic drug, cisplatinum, can mobilize skeletal lead. In vivo measurements of lead and platinum in the kidney of chemotherapy patients were performed with the technique of x-ray fluorescence, using 99mTc in a backscatter geometry. The results of the pilot study were inconclusive; the majority of patients exhibited no evidence of kidney lead at the level of system sensitivity, and negligible blood and urine lead levels.
ISSN:0969-8051
1872-9614
DOI:10.1016/0969-8051(93)90027-R