Fetal organs infected by HIV-1

The transmission rate of HIV from mother to fetus via the placenta is estimated to be 12-50% (1-3). Because differences in fetal outcome may be influenced by time of viral transmission in utero and type of infected fetal cell, we examined 28 embryos/fetuses (10-27th week of gestation) by polymerase...

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Veröffentlicht in:	AIDS (London) 1993-06, Vol.7 (6), p.896-897
Hauptverfasser:	Backé, E, Unger, M, Jimenez, E, Siegel, G, Schäfer, A, Vogel, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV DNA, Viral - analysis Female Fetus - microbiology Gestational Age HIV - isolation & purification HIV Infections - embryology HIV Infections - microbiology HIV Infections - transmission human immunodeficiency virus 1 Humans In Situ Hybridization Lymphoid Tissue - embryology Lymphoid Tissue - microbiology Maternal-Fetal Exchange Organ Specificity Placenta - microbiology Placenta - physiology Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious Proviruses - isolation & purification RNA, Viral - analysis Viscera - embryology Viscera - microbiology
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Beschreibung
Zusammenfassung:	The transmission rate of HIV from mother to fetus via the placenta is estimated to be 12-50% (1-3). Because differences in fetal outcome may be influenced by time of viral transmission in utero and type of infected fetal cell, we examined 28 embryos/fetuses (10-27th week of gestation) by polymerase chain reaction (PCR), RNA in situ hybridization and immunostaining (not all cases were investigated by all three methods).
ISSN:	0269-9370
DOI:	10.1097/00002030-199306000-00025